Safety and Efficacy of Aortic Root Reinforcement Combined With Vascular Grafts Eversion and built-in Procedure (XJ-procedure) in Patients With Acute Type A Aortic Dissection (ADVANCED-XJ ): an Investigator-initiated, Single-center, Cohort Study
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Type A Aortic Dissection
- 发起方
- First Affiliated Hospital Xi'an Jiaotong University
- 入组人数
- 183
- 试验地点
- 1
- 主要终点
- 30-day mortality
- 状态
- 已完成
- 最后更新
- 2年前
概览
简要总结
This is a retrospective study based on the data available in our hospital database for ATAAD patients from January 2020 to December 2021. These patients were divided into two groups according to the surgical procedures of aortic root. This study compared baseline data, perioperative and short-term follow-up results between the two groups to evaluate the efficacy and safety of XJ-procedure in ATAAD.
详细描述
Acute type A aortic dissection (ATAAD) is a life-threatening disease with high mortality. Surgery remains the gold standard for the treatment of ATAAD. In recent years, ATAAD is still a persistent challenge for cardiovascular surgeons. This is a retrospective study based on the data available in our hospital database for ATAAD patients undergoing total aortic arch replacement with elephant trunk stent under cryogenic stop circulation from January 2020 to December 2021. These patients were divided into two groups according to the surgical procedures of aortic root: continuous aortic root suture group (CARS group); "aortic root reinforcement combined with vascular grafts eversion and built-in", which was created by our group and to be named as XJ-procedure (XJ-procedure group, XJ is an acronym for Xi'an Jiaotong University). The main outcome was defined as 30-day mortality. Secondary outcomes included the postoperative bleeding necessitating re-operation and the incidence of anastomotic pseudoaneurysm, residual aortic root dissection and severe aortic regurgitation before discharge and at 3 and 6 months after the operation. This study compared baseline data, perioperative and short-term follow-up results between the two groups to evaluate the efficacy and safety of XJ-procedure in ATAAD.
研究者
入排标准
入选标准
- •Diagnosed with ATAAD by computed tomography angiography (CTA) from January 2020 to December 2021 in the First Affiliated Hospital of Xi'an Jiaotong University
- •Mild to moderate aortic root involvement
- •Aortic arch involvement undergoing Sun's procedure
排除标准
- •Patients with severe aortic root involvement (root diameter \>45 mm, root tear, severe disruption of aortic root, concomitant valve disease)
- •The Bentall, Wheat or David procedure performed
- •Recurrent ATAAD
- •Preoperative severe brain complications (cerebral infarction, cerebral hemorrhage, coma, etc.)
- •Mal-perfusion of abdominal organs or lower extremities \>12 h
- •Incomplete clinical data.
结局指标
主要结局
30-day mortality
时间窗: Within 30 days after the surgery
Patients died within 30 days after the surgery. Data were obtained from the medical records.
次要结局
- The postoperative bleeding necessitating re-operation(About 2 weeks after the surgery.)
- Change in the incidence of anastomotic pseudoaneurysm(About 2 weeks after surgery, 3-month and 6-month follow-up.)
- Change in the incidence of residual aortic root dissection(About 2 weeks after surgery, 3-month and 6-month follow-up.)
- Change in the incidence of severe aortic regurgitation(About 2 weeks after surgery, 3-month and 6-month follow-up.)