Application of CfDNA Methylation Detection in Auxiliary Diagnosis of Breast Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Establish DNA methylation profiles of two populations by collecting tissues and peripheral blood related to benign and malignant breast nodules.
研究概览
简要总结
The purpose of this study is to construct an auxiliary diagnostic model for breast cancer by methylation markers. The study will collect blood and tissue samples from participants with breast cancer and benign disease for whole-genome methylation sequencing. It will screen methylation markers and develop a methylation auxiliary diagnosis model to distinguish between breast cancer and non-cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Establish DNA methylation profiles of two populations by collecting tissues and peripheral blood related to benign and malignant breast nodules.
时间窗: 12 months
Based on DNA methylation profiles, systematically evaluate the signal, noise, and complementarity of methylation biomarkers and ultimately form a set of diagnostic biomarker combinations for breast malignant nodules.
时间窗: 12 months
Further develop a methylation assisted diagnostic model that can effectively distinguish between benign and malignant breast nodules.
时间窗: 12 months
次要结局
- Evaluate the contribution and performance of methylation assisted diagnostic models by integrating imaging and methylation assisted diagnostic model results, and clarify the specificity and sensitivity of integrated model diagnosis.(12 months)