Methylation of cfDNA in Diagnosis and Differential Diagnosis of Ovarian Endometriosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Circulating Free DNA
- Sponsor
- Peking Union Medical College Hospital
- Enrollment
- 390
- Locations
- 1
- Primary Endpoint
- The efficacy of cfDNA methylation in the diagnosis of ovarian endometriosis
- Last Updated
- 6 years ago
Overview
Brief Summary
Methylation detection of circulating free DNA to identify markers for diagnosis and differential diagnosis of ovarian endometriosis.
Detailed Description
Methylation detection of circulating free DNA and FFPF samples from patients with ovarian endometriosis, ovarian cancer and other benign ovarian cysts will be performed to select markers for ovarian endometriosis diagnosis. The markers will be validated in patients with ovarian cysts found by ultrasound. The diagnosis accuracy of the markers will be evaluated by comparing with the pathological diagnosis.
Investigators
shuwang
Associate Professor
Peking Union Medical College Hospital
Eligibility Criteria
Inclusion Criteria
- •pathologically diagnosed as ovarian endometriosis;
- •surgery was performed in PUMCH
Exclusion Criteria
- •a. combined with other gynecological benign and malignant tumors; b. clinically suspected malignant tumors; c. combined with other systemic malignancies or malignancies history; d. pregnant patients
- •patients with ovarian cancer:
- •Inclusion Criteria:
- •pathologically diagnosed as epithelial ovarian cancer;
- •surgery was performed in PUMCH
- •Exclusion Criteria:
- •combined with gynecological benign tumors and other malignant tumors;
- •combined with other systemic malignancies or malignancies history;
- •pregnant patients (3) patients with other benign ovarian tumors:
- •Inclusion Criteria:
Outcomes
Primary Outcomes
The efficacy of cfDNA methylation in the diagnosis of ovarian endometriosis
Time Frame: 12 months
The sensitivity, specificity and accuracy are calculated according to standard definitions to evaluate the efficacy of cfDNA methylation in the diagnosis of ovarian endometriosis