eurological underpinnings of cognitive dysfunctions in breast cancer patients - Neurological underpinnings of cognitive dysfunctions in breast cancer patients
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 80
研究概览
简要总结
We found a significant interaction between regional grey matter volume (rGMV) in the thalamus (P < 0.05, familywise error (FWE), small volume correction (SVC)) and one attention domain subtest (P = 0.001, Bonferroni correction) after surgery in the patient group compared with the control group. Furthermore, the changes in attention were significantly associated with sevoflurane anesthetic dose (P = 0.032) and marginally associated with rGMV changes in the thalamus (P = 0.07, FWE, SVC) in the Pt group.We found a significant interaction between regional grey matter volume (rGMV) in the thalamus (P < 0.05, familywise error (FWE), small volume correction (SVC)) and one attention domain subtest (P = 0.001, Bonferroni correction) after surgery in the patient group compared with the control group. Furthermore, the changes in attention were significantly associated with sevoflurane anesthetic dose (P = 0.032) and marginally associated with rGMV changes in the thalamus (P = 0.07, FWE, SVC) in the Pt group.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- ot applicable 至 80years-old（—）
- 性别
- Female
入选标准
- 未提供
排除标准
- •Previous history of cancer therapy with drug Metastatic cancer History of any neurological condition, traumatic brain injury, mental retardation, use of psychotropic medication, drug or alcohol abuse Any contraindication to undergoing on MRI use