Glymphatic dysfunction in cognitive impairment: a memory clinic study - GlyM

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 120 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•Patients with Alzheimer's disease (AD) dementia:
•-Diagnosis of dementia of the AD type (McKhann et al. 2011)
•-Age > 55 years
•-Mentally competent (MMSE>=18) and able to give informed consent
•-Informed consent before participation in the study
•Patients with Mild cognitive impairments (MCI) or Subjective cognitive
•impairment (SCI):
•-Diagnosis of MCI (Albert et al. 2011) or diagnosis of Mild Neurocognitive
•Disorder (DSM V) (Sachs-Ericsson and Blazer 2015) or diagnosis of SCI as given
•by the memory clinic (SCI is defined by an individual experiencing subjective
•complaints and visiting the memory clinic for these complaints, but not showing
•a significant decline in objective cognitive assessment)
•-Age > 55 years
•-Mentally component (MMSE >=18) and able to give informed consent
•-Informed consent before participation in the study
•Control subjects:
•-Mini-Mental State Examination (MMSE) >= 26
•-Age > 55 years
•-Mentally component (MMSE >=18) and able to give informed consent
•-Informed consent before participation in the study

•- Any significant disease or unstable medical condition that could influence
•neuropsychological testing (with the exception of a SCI, MCI or AD diagnosis)
•- Major depression (according to the DSM IV) (< 12 months ago)
•- Psychiatric history (schizophrenia, schizoaffective disorder, bipolar
•disorder or any his-tory of electroconvulsive therapy)
•- Vascular dementia
•- Ischemic or valvular heart disease or electrocardiographic evidence of atrial
•fibrillation
•- Recent transient ischemic attacks and ischemic or haemorrhagic stroke or
•cerebrovascular accident (< 2 years or paired with cognitive decline within 3
•months after incident)
•- Obstructive sleep apnoea syndrome
•- Normal Pressure Hydrocephalus, M. Huntington, Parkinson*s disease,
•Frontotemporal dementia, Motor neuron diseases, Multiple sclerosis, Epilepsy
•- Systemic inflammation, such as active rheumatoid arthritis
•- Diabetes
•- Cognitive impairment due to alcohol/drug abuse
•- Structural abnormalities of the brain, such as tumours or stroke lesions
•- Inability to provide informed consent
•- Any contraindication for MRI: metallic implants, pacemaker, claustrophobia,
•pregnancy, tattoos in the head/neck region (with potential exception of
•make-up after assessment with SOP permanent make-up)
•- Unwillingness to be informed about potential abnormal MRI-findings

发起方

Medisch Universitair Ziekenhuis Maastricht