eurological underpinnings of cognitive dysfunctions in breast cancer patients
- Conditions
- breast cancer
- Registration Number
- JPRN-UMIN000007287
- Lead Sponsor
- Institute of development, aging and cancer, Tohoku university
- Brief Summary
We found a significant interaction between regional grey matter volume (rGMV) in the thalamus (P < 0.05, familywise error (FWE), small volume correction (SVC)) and one attention domain subtest (P = 0.001, Bonferroni correction) after surgery in the patient group compared with the control group. Furthermore, the changes in attention were significantly associated with sevoflurane anesthetic dose (P = 0.032) and marginally associated with rGMV changes in the thalamus (P = 0.07, FWE, SVC) in the Pt group.We found a significant interaction between regional grey matter volume (rGMV) in the thalamus (P < 0.05, familywise error (FWE), small volume correction (SVC)) and one attention domain subtest (P = 0.001, Bonferroni correction) after surgery in the patient group compared with the control group. Furthermore, the changes in attention were significantly associated with sevoflurane anesthetic dose (P = 0.032) and marginally associated with rGMV changes in the thalamus (P = 0.07, FWE, SVC) in the Pt group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- Female
- Target Recruitment
- 80
Not provided
Previous history of cancer therapy with drug Metastatic cancer History of any neurological condition, traumatic brain injury, mental retardation, use of psychotropic medication, drug or alcohol abuse Any contraindication to undergoing on MRI use
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive function Brain structure
- Secondary Outcome Measures
Name Time Method Psychological measurement Estrogen