The Relationship Between White Matter Hyperintensity With Cognition and Emotion

• Conditions: Leukoaraiosis; Aged

• Registration Number: NCT02761148
• Lead Sponsor: Zhejiang University

Brief Summary

White matter hyperintensity (WMH) has been found to be related with cognitive and emotional dysfunction. A presumed mechanism is that WMH disrupts the structural connectivity within a large-scale brain network, thereby impairing the brain's ability to integrate the neural processes efficiently. It is not yet clear, what the pattern of brain network disruption relates to WMH and how the brain network disruption induced by WMH has an effect on cognition and emotion performance. Using multi-model magnetic resonance imaging (MRI) techniques, we aimed to explore the mechanisms of cognitive decline and depression related with brain network dysfunction in patients with WMH, and to provide objective imaging marker for early diagnosis and prevention of WMH associated cognitive decline and depression.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2016-05-02
• Study First Submitted QC: 2016-05-02
• Study First Posted: 2016-05-04
• Status Verified: 2017-06
• Last Update Submitted: 2017-06-10
• Last Update Posted: 2017-06-14
• Primary Completion: 2019-12
• Study Completion: 2019-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fazekas Scale of white matter hyperintensity	1 year
Mini-Mental State Examination (MMSE)	1 year
Hamilton Depression Scale (HAMD)	1 year

Trial Locations

Locations (1)

The 2nd Affiliated Hospital of Zhejiang University, School of Medicine,; 🇨🇳 Hangzhou, Zhejiang, China