Prognostic Value Cardiac Dysfunction Assessed by Bedside Echocardiography in Critically Ill COPD Patients Requiring Mechanical Ventilation

Completed

• Conditions: COPD Patients; Mechanical Ventilation
• Interventions: Device: echocardiography examination

• Registration Number: NCT02099279
• Lead Sponsor: Jinhua Central Hospital

Brief Summary

Chronic obstructive lung disease (COPD) is a major cause of morbidity and mortality, and is a major reason for ICU admission. Cardiac function is often impaired in this disease but its association with clinical outcome has not been fully established. The study aims to investigate the association between cardiac dysfunction and clinclial outcomes.

Detailed Description

This is a prospective observational study conducted in a 47-bed mixed ICU of tertiary academic teaching hospital. The study will be performed between January 2014 to December 2015. All patients meeting the diagnostic criteria of AECOPD and admitted to ICU are potentially eligible for the present study. Relevant demographics and laboratory measurements are obtained. Transthoracic echocardiography (TTE) is performed immediately after ICU admission by experienced intensivists. Cox proportional hazard regression model is fitted by using stepwise forward selection and backward elimination technique. If linear assumption is not satisfied, the linear spline function will be used.

Study Timeline

• Study Start: 2014-01
• Status Verified: 2014-03
• Study First Submitted: 2014-03-23
• Study First Submitted QC: 2014-03-25
• Study First Posted: 2014-03-28
• Primary Completion: 2015-01
• Study Completion: 2015-02
• Last Update Submitted: 2015-08-31
• Last Update Posted: 2015-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 53

Inclusion Criteria

• COPD patients experiencing episode of exacerbation and require mechanical ventilation were admitted to ICU

Exclusion Criteria

• COPD patients admitted to ICU due to other reasons (major surgery, ischemic heart disease, and renal failure)
• moribund and expected to die within 48 hours
• with Do-Not-Resuscitation order

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
echocardiography examination	echocardiography examination	-

Primary Outcome Measures

Name	Time	Method
28-day mortality	28 days after ICU admission	28 days after ICU admission; if a patient leave ICU before 28-days, it is considered as censored.

Secondary Outcome Measures

Name	Time	Method
duration of mechanical ventilation	from ICU admission to extubation, an expected average of 8 days

Trial Locations

Locations (1)

Jinhua municipal central hospital; 🇨🇳 Jinhua, Zhejiang, China