Determining the correlation between echocardiographic blood flow velocity changes and breath holding maneuver to evaluate whether a hypotensive patient on ventilator support will be benefitted by further intravenous fluid therapy

Not yet recruiting

• Conditions: Diseases of the circulatory system,

• Registration Number: CTRI/2019/12/022450
• Lead Sponsor: ALL INDIA INSTITUTE OF MEDICAL SCIENCES NEW DELHI

Brief Summary

Fluidadministration is the first-line therapy in patients with acute circulatoryfailure. Except in cases of cardiogenic shock, fluid depletionor hypovolemia is the primary cause of acute circulatory failure. Hence fluidresuscitation is essential in the early phases of shock, particularly in casesof sepsis. In our prospectiveobservational study, we plan to compare pulmonary arterial velocity time integral variation, Aortic velocity timeintegral variation and inspiratory pause maneuver to predict fluidresponsiveness in mechanically ventilated, acute circulatory failure patients.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-12-16
• Study Start: 2019-12-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

• 1.Mechanically ventilated patients of age 18 years and more admitted in the ICU.
• 2.Patients with Acute circulatory failure – presence of any one of the following.
• Systolic blood pressure <90 mm Hg or MAP < 65 mmHg -Need of vasopressors to maintain systolic blood pressure > 90 mmHg. -Urine output < 0.5ml/kg/hour for 2 hours -Heart rate > 100 /min.

Exclusion Criteria

Patients not in sinus rhythm Patients with low tidal volumes (less than 6 ml/kg) Patients with known cardiac valvular dysfunction Right heart failure Patients with very high respiratory rate (HR/RR <3.6) Morbid obesity-BMI ≥35 kg/m2 Poor echocardiographic window.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate the correlation between pulmonary arterial velocity time integral variation, aortic velocity time integral variation and inspiratory pause maneuver to predict fluid responsiveness in mechanically ventilated patients with acute circulatory failure.	1 day

Secondary Outcome Measures

Name	Time	Method
To determine sensitivity, specificity, positive predictive value and negative predictive value of pulmonary arterial velocity time integral variation, aortic velocity time integral variation and inspiratory pause maneuver to predict fluid responsiveness in mechanically ventilated patients with acute circulatory failure.	1 day

Trial Locations

Locations (1)

All India Institute of Medical Sciences; 🇮🇳 West, DELHI, India

All India Institute of Medical Sciences

🇮🇳West, DELHI, India

Shanmugam R

Principal investigator

8810516233

roshanmugam@gmail.com