CTRI/2019/12/022450Not yet recruitingNot Applicable
Use of pulmonary arterial velocity time integral variation and effect of inspiratory pause in predicting fluid responsiveness in acute circulatory failure
ALL INDIA INSTITUTE OF MEDICAL SCIENCES NEW DELHI1 site in 1 country101 target enrollmentStarted: December 25, 2019Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 101
- Locations
- 1
- Primary Endpoint
- To evaluate the correlation between pulmonary arterial velocity time integral variation, aortic velocity time integral variation and inspiratory pause maneuver to predict fluid responsiveness in mechanically ventilated patients with acute circulatory failure.
Study Overview
Brief Summary
Fluidadministration is the first-line therapy in patients with acute circulatoryfailure. Except in cases of cardiogenic shock, fluid depletionor hypovolemia is the primary cause of acute circulatory failure. Hence fluidresuscitation is essential in the early phases of shock, particularly in casesof sepsis. In our prospectiveobservational study, we plan to compare pulmonary arterial velocity time integral variation, Aortic velocity timeintegral variation and inspiratory pause maneuver to predict fluidresponsiveness in mechanically ventilated, acute circulatory failure patients.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18.00 Year(s) to 80.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •1.Mechanically ventilated patients of age 18 years and more admitted in the ICU.
- •2.Patients with Acute circulatory failure – presence of any one of the following.
- •Systolic blood pressure <90 mm Hg or MAP < 65 mmHg -Need of vasopressors to maintain systolic blood pressure > 90 mmHg. -Urine output < 0.5ml/kg/hour for 2 hours -Heart rate > 100 /min.
Exclusion Criteria
- •Patients not in sinus rhythm Patients with low tidal volumes (less than 6 ml/kg) Patients with known cardiac valvular dysfunction Right heart failure Patients with very high respiratory rate (HR/RR <3.6) Morbid obesity-BMI ≥35 kg/m2 Poor echocardiographic window.
Outcomes
Primary Outcomes
To evaluate the correlation between pulmonary arterial velocity time integral variation, aortic velocity time integral variation and inspiratory pause maneuver to predict fluid responsiveness in mechanically ventilated patients with acute circulatory failure.
Time Frame: 1 day
Secondary Outcomes
- To determine sensitivity, specificity, positive predictive value and negative predictive value of pulmonary arterial velocity time integral variation, aortic velocity time integral variation and inspiratory pause maneuver to predict fluid responsiveness in mechanically ventilated patients with acute circulatory failure.(1 day)
Investigators
Study Sites (1)
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