Efficacy of Manuka honey CycloPower ophthalmic cream in managing blepharitis

Not Applicable

Completed

• Conditions: Blepharitis; Eye - Diseases / disorders of the eye

• Registration Number: ACTRN12616000539437
• Lead Sponsor: The University of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-04-27
• Study Completion: 2018-06-07
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 53

Inclusion Criteria

Males or females
- Age 18 years or over
- Normal lid / lash anatomy, and closure
- Clinically significant signs of blepharitis and symptoms of dry eye

Exclusion Criteria

- Contact lens wearers unwilling to remove lenses 48 hours prior to commencement of, and for the duration of, the study.
- Ocular surgery (such as refractive or cataract surgery) in either eye within 3 months of the screening visit
- A systemic condition or disease not stabilized or judged by the investigator to be incompatible with participation in the study (e.g. current systemic infection, uncontrolled autoimmune disease, uncontrolled immunodeficiency disease, history of myocardial infarction, etc.)
- The history or presence of any significant skin condition or disorder that might interfere with the study outcomes.
- The history or presence of any ocular disorder or condition in either eye that would likely interfere with the interpretation of the study results or patient safety such as a significant reduction in visual acuity e.g. less than 20/200; significant corneal or conjunctival scarring, pterygium or nodular pinguecula; current ocular infection or inflammation unrelated to dry eye; anterior (epithelial) basement membrane corneal dystrophy or other clinically significant corneal dystrophy or degeneration; ocular herpetic infection, etc.
- Known hypersensitivity to any of the components of the study preparation or bee products
- Active or uncontrolled severe systemic allergy, chronic seasonal allergies, rhinitis or sinusitis requiring treatment (i.e. antihistamines, decongestants, oral or aerosol steroids) at the time of screening
- Use of medication known to cause ocular drying (e.g., cyclosporine, antihistamines, tricyclic antidepressants, anxiolytics, antimuscarinics, beta-blocking agents, diuretics, phenothiazines, steroids, etc.) within 30 days of the screening visit
- Punctal plugs (unless permanent)
- Participation in any clinical trial with a new active substance or a new device during the past 30
- Women who are pregnant, planning a pregnancy or nursing at study entry.

Study & Design

• Study Type: Interventional
• Study Design: Not specified