Effect of Garlic on Gut microbiota, Inflammation & Cognition in hypertensives: The GarGIC trial

Not Applicable

Completed

• Conditions: hypertension; Cardiovascular - Hypertension; Alternative and Complementary Medicine - Herbal remedies; Inflammatory and Immune System - Normal development and function of the immune system

• Registration Number: ACTRN12616000185460
• Lead Sponsor: A/Prof Dr Karin Ried

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-12
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Inclusion criteria
- Essential hypertension: Mean systolic SBP >=140 mm Hg or diastolic blood pressure >=90 mm Hg to be confirmed under trial conditions at the screening appointment (at screening mean DBP of >=88 / SBP >=135 mm Hg will be included)
- Either not on blood pressure medication, or on established plan of blood pressure medication (one or more classes) for at least 2 months
- The patient’s doctor is not planning to change current treatment during the 3 month trial
- Able to give informed consent

Exclusion Criteria

Exclusion criteria
- Poor comprehension of written or spoken English
- Current or previous antibiotic treatment within the last 2 months of study enrolment
- Currently taking anti-inflammatory agents, glucocorticoids or other immune regulating prescription medication
- Currently taking probiotics
- Currently taking garlic supplements
- History of intestinal surgery, inflammatory bowel disease, celiac disease, lactose intolerance, chronic pancreatitis, or diagnosed malabsorption disorder
- Planning surgery in the next 3-4 months
- Unstable other medical conditions or serious illness, at the discretion of the GP, e.g. dementia, terminal illness, recent bereavement, secondary hypertension, recent significant medical diagnosis, and pregnancy
- Severe hypertension (mean sitting SBP>=180 mm Hg and DBP >=110 mm Hg) at enrolment or subsequent visits during the study. Patients with severe hypertension will be referred back to their doctor for further management

Study & Design

• Study Type: Interventional
• Study Design: Not specified