Effect on Early Cognition Under Sedation by Rimazole Toluenesulfonate in Old Patient Undergoing Colonoscopy
- Conditions
- Cognition
- Interventions
- Registration Number
- NCT05255211
- Lead Sponsor
- RenJi Hospital
- Brief Summary
To investigate the effect on cognition under sedation by Rimazole toluenesulfonatein elderly patients undergoing colonoscopy
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 90
- ASA I~II
- patients will be treatmented by sedation under colonoscopy
- sign informed consent
(1) Preoperative depression and cognitive impairment
（2） Hearing or visual impairment;
（3） Drug abuse, alcoholism or long-term use of antidepressants;
（4） Cardiovascular and cerebrovascular accidents, neurological sequelae, or severe liver and kidney function damage occurred within 6 months
（5） BMI < 18, BMI > 30
（6） Confirmed or suspected allergy to the test drug
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Remimazolam Remimazolam tosilate IV Remimazolam tosilate 0.3mg/kg propofol Propofol IV propofol 1.2\~2.5mg/kg saline saline solution IV saline solution 10ml
- Primary Outcome Measures
Name Time Method Mini-mental State Examination(MMSE) score 1 5 minutes before procedure The MMSE scoring standard is the preferred scale for dementia screening. It can comprehensively, accurately and quickly reflect the mental state and cognitive defects of the subjects.The values is 0\~30.
Cognitive dysfunction: the highest score is 30 points, the score is normal at 27-30, and the score \<27 is cognitive dysfunction; Dementia classification criteria: illiteracy ≤ 17, primary school level ≤ 20, secondary school level (including technical secondary school) ≤ 22 points, university level (including junior college) ≤ 23 points; 3. Dementia severity classification: mild MMSE ≥21 points; moderate, MMSE 10-20 points; severe, MMSE ≤9 points;Mini-mental State Examination(MMSE) score 2 30 minutes after colonoscopy when VAAS score>=4 The MMSE scoring standard is the preferred scale for dementia screening. It can comprehensively, accurately and quickly reflect the mental state and cognitive defects of the subjects.The values is 0\~30.
Cognitive dysfunction: the highest score is 30 points, the score is normal at 27-30, and the score \<27 is cognitive dysfunction; Dementia classification criteria: illiteracy ≤ 17, primary school level ≤ 20, secondary school level (including technical secondary school) ≤ 22 points, university level (including junior college) ≤ 23 points; 3. Dementia severity classification: mild MMSE ≥21 points; moderate, MMSE 10-20 points; severe, MMSE ≤9 points;
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Yongming Chen
🇨🇳Shanghai, Shanghai, China