Impact of Renal Replacement Therapy on Coagulation Profile of Patients with Acute Renal Failure

Completed

• Conditions: Acute Renal Failure; Hemorrhage; Coagulation Disorder

• Registration Number: NCT03536195
• Lead Sponsor: University Hospital, Brest

Brief Summary

Renal failure and high plasmatic level of urea have been associated with an increased risk of hemorrhage in surgical patients. There is only sparse data on the impact of renal replacement therapy on homeostatic parameters. The aim of this study is to describe potential changes in homeostatic parameters before and after renal replacement therapy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-04-25
• Study First Submitted QC: 2018-05-14
• Study First Posted: 2018-05-24
• Study Start: 2018-08-18
• Primary Completion: 2021-11-23
• Study Completion: 2021-11-23
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-20
• Last Update Posted: 2025-03-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• critically ill patients
• acute renal failure
• renal replacement therapy
• plasmatic urea > 20

Exclusion Criteria

• chronic renal failure
• platelet count less than 80 Giga
• V factor less than 70%

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
visco elastometry	Change in ROTEM parameters from baseline to after renal replacement therapy	ROTEM (Rotational Thromboelastometry)

Trial Locations

Locations (1)

CHRU de Brest; 🇫🇷 Brest, France