Improved Visualization of Glioblastoma Using Delayed 18F-FDG PET/CT.
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Tumor-to-background ratio on delayed scans (240 min after injection)
研究概览
简要总结
This clinical trial studies how well delayed fludeoxyglucose F-18 (18F-FDG) positron emission tomography (PET)/computed tomography (CT) works in improving visualization of brain tumors in patients with glioblastoma. Radiotracers such as 18F-FDG are highly taken up by tumors in the brain and are visualized using PET/CT. Increasing the interval of time between 18F-FDG administration and PET/CT scan may improve the visualization of brain tumors in patients with glioblastoma.
详细描述
PRIMARY OBJECTIVES:
I. To improve the visualization/delineation of glioblastoma lesions using delayed 18F-FDG PET/CT imaging.
OUTLINE:
Patients receive fludeoxyglucose F-18 intravenously (IV). Patients then undergo a standard of care PET/CT scan at 60 minutes and a second PET/CT scan at 240 minutes after injection.
Note:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with histologically proven high grade glioma scheduled for 18F-FDG PET/CT
排除标准
- •Severe psychiatric illness
- •Inability to give written consent
- •Breast feeding/pregnancy
结局指标
主要结局
Tumor-to-background ratio on delayed scans (240 min after injection)
时间窗: Baseline up to 240 minutes after injection
Ratio between Standardized uptake values (tumor region) and Standardized uptake values (physiological uptake of brain tissue)
Tumor-to-background ratio on standard scans (60 min after injection)
时间窗: Baseline up to 60 minutes after injection
Ratio between Standardized uptake values (tumor region) and Standardized uptake values (physiological uptake of brain tissue)
次要结局
- Standard uptake value comparison(60 minutes post injection)