Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy

Not Applicable

Completed

• Conditions: Type 2 Diabetes Mellitus; Chronic Periodontitis
• Interventions: Procedure: non-surgical periodontal therapy

• Registration Number: NCT02174146
• Lead Sponsor: Cairo University

Brief Summary

1. Are adipokines involved in pathogenesis of periodontal disease in diabetic patients?

2. Does their level change after periodontal therapy?

Detailed Description

Patients with chronic periodontitis only and patients with chronic periodontitis and diabetes were evaluated for levels of leptin and visfatin in the gingival tissues before and after non-surgical periodontal therapy.

Study Timeline

• Study Start: 2013-09
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Status Verified: 2014-06
• Study First Submitted: 2014-06-23
• Study First Submitted QC: 2014-06-23
• Last Update Submitted: 2014-06-23
• Study First Posted: 2014-06-25
• Last Update Posted: 2014-06-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• diabetic patients having diabetes mellitus ≥5 years prior to the study.
• chronic periodontitis with clinical attachment loss > 5 mm.
• otherwise systemically healthy subjects.

Exclusion Criteria

• any known systemic diseases other than diabetes.
• pregnancy or lactation.
• smokers.
• receiving periodontal treatment in the last 6 months.
• taking any drugs or medications other than anti-diabetic drugs.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
non-surgical therapy	non-surgical periodontal therapy	non-surgical periodontal therapy with ultrasonic scalers and periodontal curettes

Primary Outcome Measures

Name	Time	Method
visfatin levels in gingival tissues	3 months	estimation of protein and gene expression of visfatin in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy..
leptin levels in gingival tissue	3 months	estimation of protein and gene expression of leptin in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy..

Secondary Outcome Measures

Name	Time	Method
pocket depth	3 months	estimation of pocket depth in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy.
clinical attachment level	3 months	estimation of clinical attachment level in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy.

Trial Locations

Locations (1)

Faculty of oral and dental medicine; 🇪🇬 Cairo, Egypt