Proton Pump Inhibitors and Dysbiosis in Cirrhosis
- Registration Number
- NCT01458990
- Lead Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
- Brief Summary
The purpose of this study is to find out whether the use of medications that suppress acid in your stomach can change the composition of your bowel bacteria.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description PPI inititation Omeprazole Adding 40mg omeprazole QD for 14 days PPI withdrawal Omeprazole The intervention here is systematically withdrawing chronic PPI for 14 days
- Primary Outcome Measures
Name Time Method Number of Patients With Overgrowth of Oral Microbiota in Their Stool After PPI Therapy Withdrawal or Initiation 2 weeks Analysis at baseline will be compared to that at 2 weeks using Multitagged sequencing. Number of patients with overgrowth of oral microbiota in their stool after PPI therapy withdrawal or initiation were specifically analyzed.
- Secondary Outcome Measures
Name Time Method Number of Patients With Adverse Events During Initiation or Withdrawal of PPI Therapy 2 weeks Analysis at baseline will be compared to that at 2 weeks. This will be specifically, changes in those with PPI withdrawal compared to those with PPI initiation
Trial Locations
- Locations (1)
Hunter Holmes McGuire VA Medical Center
🇺🇸Richmond, Virginia, United States