Proton Pump Inhibitors in Cirrhotic Patients
- Conditions
- Proton Pump Inhibitor Adverse ReactionLiver Cirrhosis
- Registration Number
- NCT06384443
- Lead Sponsor
- National Liver Institute, Egypt
- Brief Summary
Proton pump inhibitors (PPIs) inappropriate use, in patients with cirrhosis, presents a significant clinical challenge. This study evaluates overprescription and misuse of PPIs in cirrhotic patients. The patterns of use of PPIs will be classified into two groups based on adherence to the proven indications: Group A: Inappropriate use of PPI, Group B: Appropriate use of PPI. We will estimate the prevalence of PPI misuse in cirrhotics and correlate it with different factors.
- Detailed Description
The inappropriate use of PPIs in cirrhosis patients is a growing concern. Evidence supporting the use of PPIs in cirrhosis-related conditions is limited. Several adverse outcomes have been linked to PPI use in cirrhosis, including an increased risk of spontaneous bacterial peritonitis and hepatic encephalopathy.
The study aimed to assess the appropriateness of prescribing PPIs to patients with cirrhosis, examining its impact on prescribing practices and identifying associated factors.
in this observational, descriptive, cross-sectional study, cirrhotic patients receiving proton pump inhibitors will be included in the study. Enrolled patients will classified according to the indication for PPI administration: Group A: Inappropriate use of PPI, Group B: Appropriate use of PPI. Use of PPI will be considered inappropriate when prescribed without approved indication or used for a prolonged period beyond the recommended duration. The prevalence of PPI misuse in cirrhotics will be estimated and multivariate analyses will be conducted in order to identify independent predictors of inappropriate use of PPI.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1000
- Patients receiving proton pump inhibitors at the time of enrollment.
- Refusal to sign the informed consent form or failure to provide the required information
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Predictors for inappropriate use of PPIs Eight weeks after study completion Determine independent predictors of inappropriate use of PPIs in patients with liver cirrhosis using multivariate analyses.
Inappropriate use of PPIs Six weeks after study completion Explore the prevalence of using PPIs without approved indication or for a prolonged period beyond the recommended duration in patients with liver cirrhosis
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
National Liver institute - Menoufia University
🇪🇬Shibīn Al Kawm, Menoufia, Egypt