Are we giving appropriate dose of tranexamic acid in hip replacement surgery?

Not Applicable

• Conditions: Joint replacement surgery; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12619000670178
• Lead Sponsor: sha Gurunathan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-05-06
• Last Update Posted: 28 June 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Patient undergoing unilateral total hip replacment and receiving tranexamic acid; Age greater than or equal to 18 years old; Written informed consent obtained from the patient

Exclusion Criteria

Consent not obtained; Patients in whom tranexamic acid would be contraindicated such as cerebrovascular or coronary event in the past 12 months, end stage renal disease, those at a very high risk of thromboembolism, or documented allergy etc; Patients with communication barrier due to language issues; Urgent arthroplasty or hemiarthroplasty due to hip fractures; Bilateral THR

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma concentration of tranexamic acid at various time points.<br>[at baseline, post tranexamic acid administration - at 5 minutes, skin incision, skin closure, 3 hours, 8 hours];Tranexamic acid exposure time, when plasma concentration of tranexamic acid is above the minimum threshold.[until 8 hours post tranexamic acid administration]