Study on the effects of hyperoxemia on hemodynamic parameters and cardiac functio

Completed

Conditions: Hemodynamic changes
microcirculation
10082206
10062915
10011954

Registration Number: NL-OMON40934

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

- Scheduled for ventilation and sedation at the ICU after elective coronary artery bypass grafting
- Aged 18-65 years
- Being able to give written informed consent prior to surgery

Exclusion Criteria

- Pregnancy
- Hemodynamic instability with a mean arterial pressure (MAP) < 70 mm Hg, central venous pressure (CVP) >18 mm Hg and / or dependence on moderate to high dosages of inotropic drugs after admittance to the ICU (noradrenalin > 0.1 ug/kg/min or dobutamin > 5 ug/kg/min or adrenalin at any dose or milrinone > 0.6 ug/kg/min
- Severe arrhythmias
- Intra-cardiac shunts
- Symptomatic peripheral vascular disease
- Symptomatic pulmonary disease
- Clinically significant aortic aneurysm
- Significant valvular regurgitation
- Prior diagnosis of aberrant cardiovascular anatomy

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cardiac Output<br /><br>Blood flow arteria cerebri media rechts<br /><br>Microcirculation </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Mean arterial pressure<br /><br>Stroke Volume (Variation)<br /><br>Pulse Pressure (Variation)<br /><br>Systemic Vascular Resistance<br /><br>Heart rate</p><br>