The effects of hyperoxia on organ dysfunction and outcome in critically ill patients with SIRS

Phase 4

Completed

• Conditions: orgaandysfunctie en SIRS; systemic inflammatory response syndrome

• Registration Number: NL-OMON44818
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 385

Inclusion Criteria

-Age *18 years
-*2 positive SIRS-criteria:
Temperature >38oC or hypothermia <36oC
Heart rate >90 bpm
Respiratory rate >20 /min or pCO2 <32 mmHg (4.3 kPa)
Number of leucocytes >12 x 109/l of <4 x 109/l of >10% bands
-Within 24 hours of admittance to the ICU
-Expected stay of more than 48 hours as estimated by the attending physician

Exclusion Criteria

-Elective surgery
-carbon monoxide poisoning
-Cyanide intoxication
-Methemoglobinemia
-Sickle cell anemia
-Known severe pulmonary arterial hypertension (WHO class III or IV)
-Known severe ARDS (Berlin criteria)
-Cardiac right to left shunting
-Pregnancy
-Severe COPD (Gold class III or IV)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome will be the cumulative delta Sequential Organ Failure<br /><br>(SOFA) score in the first 14 days). </p><br>