Defining The Quality Of Intraoperatively Salvaged Blood For Deformity Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 103
- 试验地点
- 1
- 主要终点
- Elongation Index (Deformability)
研究概览
简要总结
The actual quality of Red Blood Cells (RBCs) salvaged during spinal deformity surgery has never been rigorously evaluated. To characterize the usefulness of intraoperatively salvaged RBCs in spinal deformity surgery. The study team hopes to answer the following questions: 1) What is the quality of RBCs salvaged during spine surgery? 2) Does intraoperatively transfused RBC salvage impact clinical outcomes?
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any/all patients undergoing spine surgery who utilizes Cell Saver and has blood to be given back.
- •This will include pediatric patients 0-17 as well as adults of any age who have been indicated for surgery.
- •Only patients with the capacity to consent will be included.
排除标准
- •Patients indicated for spinal surgery without the use of Cell Saver.
结局指标
主要结局
Elongation Index (Deformability)
时间窗: Day 1 (Day of Surgery)
Ektacytometry will be employed to measure elongation index of salvaged RBCs.
Lactate Dehydrogenase (LDH) Levels
时间窗: Day 1 (Day of Surgery)
LDH assays will be performed following a standardized mechanical stress test will be used to determine whether salvaged red blood cells exhibit signs of fragility ex vivo.
Hemoglobin Levels
时间窗: Day 1 (Day of Surgery)
Hemoglobin assays will be performed following a standardized mechanical stress test will be used to determine whether salvaged red blood cells exhibit signs of fragility ex vivo.
Critical Shear Stress (Aggregation)
时间窗: Day 1 (Day of Surgery)
Ektacytometry will be employed to measure critical shear stress of salvaged RBCs.
次要结局
- Use of Cell Saver(Day 1 (Day of Surgery))
- Units of allogeneic blood transfused intraoperatively(Day 1 (Day of Surgery))
- Standardized Quantified Blood Loss (mL)(Day 1 (Day of Surgery))
- Units of autologous blood transfused intraoperatively(Day 1 (Day of Surgery))
- Duration of pressor use(1 Day (Day of Surgery))
- Volume (mL) collected via Cell Saver(Day 1 (Day of Surgery))
- Units of allogeneic blood transfused postoperatively(Day 1 (Day of Surgery))