Preimplantation Genetic Screening in Women Over 35 Year
Not Applicable
Completed
- Conditions
- In Vitro Fertilization
- Interventions
- Procedure: Preimplantation genetic screening after embryo biopsy
- Registration Number
- NCT00593671
- Lead Sponsor
- KU Leuven
- Brief Summary
In view of insufficient evidence to routinely use Preimplantation Genetic Screening (PGS) to improve success rates after IVF, we test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer (ET) of chromosomally normal embryos following PGS compared to patients who had an ET without PGS.
In a randomized controlled trial (RCT) in patients with AMA (≥ 35 years), the clinical IR per embryo transferred will be compared after ET on day 5 or 6 between the PGS group (embryo biopsy and analysis of chromosomes 13, 16, 18, 21, 22, X and Y) and the control group without PGS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- All couples with a medical indication for IVF and with a female age of at least 35 years are invited to participate in the study.
Exclusion Criteria
- Cycles were excluded from the study if ≤ 2 fertilized oocytes were available on day 1 after oocyte retrieval (OR), or if ≤ 2 ≥ 6c stage embryos were available on day 3 after OR.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description PGS group Preimplantation genetic screening after embryo biopsy -
- Primary Outcome Measures
Name Time Method Clinical implantation rate per embryo transferred end of study
- Secondary Outcome Measures
Name Time Method Pregnancy rate per transfer end of study
Trial Locations
- Locations (1)
Leuven University Fertility Center
🇧🇪Leuven, Belgium