The role and mechanism of cGAS/STING sensing DNA damage in initiating cell senescence in degenerative osteoarthritis

Shanghai Tenth People's Hospital0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

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•(1) The diagnostic criteria of KOA conform to American College of Rheumatology (ACR);
•(2) Kellgren-Lawrence (K-L) staging is stage I, stage II or stage III;
•(3) The heart, lung, liver, and kidney functions are good, and they can tolerate ESWT;
•(4) No drugs or knee arthroscopic surgery has been used for treatment in the past 3 months;
•(5) The informed consent form was signed.

•(1) Rheumatoid arthritis, rheumatoid arthritis, traumatic arthritis, gouty arthritis;
•(2) There is a wound on the affected knee or tuberculosis, infection, osteomyelitis in the affected limb;
•(3) Suffering from vascular and neurological diseases;
•(4) The affected knee has severe varus deformity;
•(5) Combining severe primary diseases such as liver, kidney, cardiovascular and cerebrovascular and hematopoietic systems diseases;
•(6) With severe osteoporosis;
•(7) Breast-feeding or pregnant women;
•(8) Those who cannot tolerate ESWT due to pain and other factors;
•(9) The content of knee joint fluid is too small to meet the testing needs.

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