Frequency of Palpebral Involvement in Adult With Atopic Dermatitis
- Conditions
- Atopic Dermatitis
- Registration Number
- NCT04826744
- Lead Sponsor
- University Hospital, Lille
- Brief Summary
Atopic dermatitis is a common inflammatory skin disease, resulting from genetical, immunological and environmental factors. Head and neck are among the most frequent involved areas, almost 50% in adult patients according to most publications. Palpebral involvement is also common and a source of major quality of life impairment for patients.
However, the real frequency of this palpebral involvement is unknown, only estimated about 20% in few studies. The treatment of this location remains difficult, regarding to the thickness of palpebral skin and proximity of the eye.
To our knowledge, no prospective studies about allergological skin tests (such as patch-tests) in atopic patients with palpebral involvement had been conducted.
Finally, atopic dermatitis is frequently associated with ophthalmological diseases such as conjunctivitis, keratoconus or cataract, which belong to the minor criteria of Hanifin and Rakja classification.
A better knowledge of the atopic dermatitis palpebral involvement and the associated factors seems to be needed to improve the treatment and the quality of life of patients
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 550
- Atopic Dermatitis according to the revised Hanifin and Rakja criteria (UK Working Party)
- Oral consent
- Valid social insurance
- Personal history of uncontrolled asthma
- No social insurance
- Protective measures
- Age under 18
- Pregnancy or breast-feeding
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ratio of palpebral involvement in adult atopic dermatitis patients, regardless the severity of the disease At Baseline, the initial consultation of dermatology
- Secondary Outcome Measures
Name Time Method Clinical description of the palpebral involvement : acute eczema or chronic eczema At Baseline, the initial consultation of dermatology Rate of relevant contact sensitization according to the skin testing and the clinical manifestations At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours Rate of ophthalmologic comorbidities in association with palpebral involvement of the atopic dermatitis At 3 months during the time of the ophthalmologic consultation Clinical description of the ophthalmologic involvement and OSDI scoring At 3 months during the time of the ophthalmologic consultation Association between ophthalmologic involvement and severity of the atopic dermatitis At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours Potential factors associated with palpebral involvement of the atopic dermatitis (socio-demographics factors, clinical factors, comorbidities, treatment, severity …) At Baseline, (the initial consultation of dermatology ) and at 3 months during the consultation of allergology Association between allergic sensitization and severity of the atopic dermatitis At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours Association between allergic sensitization and ophthalmologic involvement At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours Description of the sensitization profile At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours
Trial Locations
- Locations (2)
Hop Claude Huriez Chu Lille
🇫🇷Lille, France
Hopital Charles Nicolle Chu Rouen
🇫🇷Rouen, France
Hop Claude Huriez Chu Lille🇫🇷Lille, France