asal High Flow Versus Conventional Oxygen Therapy in Emergency Department Patients With Asthma Exacerbation and Hypoxemia: A Randomized Controlled Trial
- Conditions
- asthma
- Registration Number
- TCTR20180926003
- Lead Sponsor
- Siriraj Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
1.Patients with age of 18 years or older
2.Patients who previously diagnosed with asthma according to GINA guideline
3.Patients who present with symptoms compatible with exacerbation according to GINA guideline (progressive increase in symptoms of shortness of breath, cough, wheezing or chest tightness and progressive decrease in lung function)
4.Patients with hypoxemia defined as SpO2 at room air of less than 95%
1.Patients with respiratory failure; defined as respiratory rate >35 breaths/min, SpO2 <90% despite oxygen supplement or signs of increased work of breathing, as observed by use of accessory muscles and abdominal asynchrony.
2.Patients with hemodynamic compromise (blood pressure <90/60 mmHg) despite intravenous fluid resuscitation
3.Patients with a Glasgow Coma Scale score less than 13
4.Patients with contraindications to the use of equipment with positive airway pressure
5.Patients previously diagnosed with COPD, lung cancer, myocardial infarction (within 3 months), renal insufficiency requiring hemodialysis
6.Patients previously smoking > 5 pack/year
7.Patients concurrently diagnosed with other lower airway conditions such as pneumonia, pulmonary edema
8.Patients who decline to participate
9.Pregnant patients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Modified Borg scale 120 minutes direct asking or questionnaire,Numeric rating scale 120 minutes direct asking or questionnaire
- Secondary Outcome Measures
Name Time Method Respiratory rate 120 minute Direct observation for one full minute,Oxygen saturation 120 minutes Pulse oxymeter,Comfort scale 120 minutes visual analog scale,Peak expiratory flow rate 120 minute peak flow meter,NIV and intubation rate 24 hours medical record review,ED and hospital length of stay after discharge medical record review