ACTRN12618000210279
Completed
Phase 3
asal High Flow therapy versus standard oxygen delivery for Children with Acute Hypoxemic Respiratory Failure - a Randomised Controlled Trial to evaluate hospital length of stay and treatment failure.
Paediatric Critical Care Research Group0 sites1,512 target enrollmentFebruary 9, 2018
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Acute respiratory failure
- Sponsor
- Paediatric Critical Care Research Group
- Enrollment
- 1512
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Children aged 1\-4 years of age (up to but excluding 5th birthday) with the clinical diagnosis of an Acute Hypoxemic Respiratory Failure disease process such as acute lower respiratory tract infection or asthma, or pnuemonia as examples, and an oxygen requirement in room air (SpO2 \<90/92%)
- •Included are infants with reactive airway disease \>12 months and an oxygen requirement in room air (SpO2 \<90/92%). This includes infants \>12 months with the diagnosis of bronchiolitis
- •Informed consent from parents or guardians
Exclusion Criteria
- •Oxygen requirement and therapy in the emergency department existed for longer than 4 hours prior to inclusion (excludes oxygen given in ambulance or other hospital)
- •Previous use of NHF therapy
- •Upper airway obstruction
- •Craniofacial malformations
- •Critically ill infants requiring immediate higher level of respiratory support i.e. NIV or invasive ventilation, low level of consciousness.
- •Basal skull fracture
- •Cyanotic Heart Disease
- •Home Oxygen therapy
- •Apnoeas (defined as requiring respiratory support such as NIV or mechanical ventilation)
- •Cystic Fibrosis
Outcomes
Primary Outcomes
Not specified
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