Agonist Gonadotropin-Releasing Hormone (GnRH) Versus Antagonist GnRH
- Registration Number
- NCT00823602
- Lead Sponsor
- Yazd Research & Clinical Center for Infertility
- Brief Summary
Literature suggests that GnRH antagonists are comparatively more often used in cycles which have an unfavorable prior prognosis, and this protocol is an ideal one for poor responder patients. Up to now, however not enough prospectives have been published to prove any beneficial effect of antagonists on the first cycle assisted reproductive technique.
This prospective study will do to evaluate the efficacy of gonadotropin releasing hormone antagonist in comparison with the standard long protocol in the first cycle of ART.
The investigators will randomize 160 patients undergoing ART for the first time . Group 1 (n=80) was stimulate with a standard long protocol and group 2 (n=80) stimulated with GnRH antagonist and then result of ART compare in two group .
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 2
- first cycle of ART
- age < 35 years
- basal FSH < 10 IU/L
- previous IVF or ICSI, hyperprolactinemia, hyperthyroidism, hypothyroidism, uterine abnormality, severe endometriosis
- only one ovary
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 ganirelix GnRH antagonist "ganirelix" 0.25 mg fromm 6th ovarian stimulation 2 suprefact GnRH agonist, suprefact, stimulation with a standard long protocol
- Primary Outcome Measures
Name Time Method pregnancy rate 2weeks
- Secondary Outcome Measures
Name Time Method ovarian stimulation 10days
Trial Locations
- Locations (1)
Yazd Research and Clinical Center For Infertility
🇮🇷Yazd, Iran, Islamic Republic of