Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor

Not Applicable

Completed

• Conditions: Pituitary Tumor
• Interventions: Drug: total intravenous anesthesia (TIVA); Drug: inhalation anesthesia group

• Registration Number: NCT02813044
• Lead Sponsor: Yonsei University

Brief Summary

A number of studies have compared the effects of total intravenous anesthesia(TIVA) versus inhalational anesthesia on perioperative period during transsphenoidal surgery. However, they have limitations especially for the phase of recovery after anesthesia: a fragmentary assessment. Quality of Recovery 40 (QoR-40) questionnaire was multi-dimensionally designed to assess the degree of recovery, specially after anesthesia and surgery. In this study, the investigators aim to compare the quality of recovery after inhalational anesthesia and after TIVA through QoR-40 questionnaire in patients undergoing transsphenoidal surgery for pituitary tumor under general anesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-06-16
• Study First Submitted: 2016-06-22
• Study First Submitted QC: 2016-06-23
• Study First Posted: 2016-06-24
• Primary Completion: 2018-06-15
• Study Completion: 2018-06-15
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-28
• Last Update Posted: 2020-09-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

• Patients over age 19
• Scheduled to undergo transsphenoidal surgery for pituitary tumor
• ASA class I and II

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Exclusion Criteria

• Left ventricular ejection fraction < 55%
• Third-degree atrioventricular block
• Second-degree atrioventricular block (P:QRS ratio of 3:1 or higher)
• Fever
• History of myocardial infarction, stroke or cardiac surgery within the previous 1 year
• Severe neurological disease
• Use of sedative, opioid or sleep-inducing drugs
• Allergic history of any study drug
• Pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TIVA group	total intravenous anesthesia (TIVA)	Anesthesia is maintained with propofol during surgery
inhalation anesthesia group	inhalation anesthesia group	Anesthesia is maintained with sevoflurane during surgery

Primary Outcome Measures

Name	Time	Method
QoR-40 score	1 day	We compare the QoR-40 scores of two groups 1 day after the operation.

Trial Locations

Locations (1)

Associate Professor Department of Anesthesiology and Pain Medicine,; 🇰🇷 Seoul, Korea, Republic of