The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume
Completed
- Conditions
- Critically Ill
- Registration Number
- NCT01344265
- Lead Sponsor
- Jinhua Central Hospital
- Brief Summary
The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 46
Inclusion Criteria
- critically ill patients who required hemodynamic monitoring using PiCCO
Exclusion Criteria
- patients with renal dysfunction
- those older than 80 years
- pregnant women
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method global end diastolic volume within 12 h after measurement of BNP this is measured by transpulmonary thermodilution technique
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Jinhua central hospital
🇨🇳Jinhua, Zhejiang, China
Jinhua central hospital🇨🇳Jinhua, Zhejiang, China