NCT00580255撤回不适用
Does Elevated Brain Natriuretic Peptide (BNP) Reflect Changes in Thoracic Impedance Levels and Affect Occurrence of Atrial and Ventricular Arrhythmias?
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
研究概览
简要总结
It is hypothesized that elevated BNP level correlate with an elevated thoracic impedance/fluid index as measured separately by CRT-D devices and external impedance cardiography. Ultimately, it is also hypothesized that both BNP and thoracic impedance/fluid index measurements are predictive of atrial and ventricular arrhythmias.
详细描述
The primary aim of this study:
- To assess the correlation between elevated brain natriuretic peptide levels and elevated thoracic impedance/body fluid index as measured by selective biventricular resynchronization devices and an external impedance cardiography device.
- Correlate impedance measurements and brain natriuretic levels with occurrence of atrial and ventricular arrhythmias as assessed by interrogation of biventricular devices.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female between 18 to 85 years of age.
- •All patients with biventricular implantable cardio-defibrillators(manufacturer: Medtronic/ model: InSync 7299/7297 or newer).
- •LVEF <35%
- •NYHA III/IV
- •QRS >120 msec
- •Pt willing and able to sign informed consent.
- •Conventional heart failure therapy
- •Clinically stable for six months.
排除标准
- •age less than 18 years of age
- •age greater than 85 years of age
- •Creatinine > 2.5 mg/dl.
- •End stage liver disease complicated by ascites as determined by electronic medical record review.
- •women who are pregnant, lactating, or plan to become pregnant during the course of the study.
- •Patients who are heart transplant candidates with expected transplantation within the next six months.
- •Life expectancy due to non-cardiac cause less than one year.
- •Anticipated problem with compliance.
- •Critical valvular stenoses/insufficiencies.
- •Morbidly obese patients(>300 lbs.)
- •In patients whom impedance cardiography was not able to be performed because of inability to place sensors.
- •Planned or known need for revascularization procedures within three months.
研究者
研究点 (1)
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