The Effect Of Simvastatin On Bone Remodeling In Socket Of Mandibular Teeth
- Registration Number
- NCT01085149
- Lead Sponsor
- Hadassah Medical Organization
- Brief Summary
Simvastatin has been reported to promote osteoblastic activity and inhibit osteoclastic activity by enhancing the expression of BMP2. There have been many studies demonstrating the bone-promoting effect of local application various animal models including after application into socket of teeth in a rat. the purpose of the study is to investigate the effect of slow release topical simvastatin in socket of mandibular teeth on bone remodeling in the socket
- Detailed Description
after extraction of mandibular single root teeth 10 mg of slow release simvastatin would be inserted to the socket. observation will be at 1 week, 4 weeks and 3 months.after 3 months the patients will have dental CT as done routinely in our clinic before placing dental implants and the bone density and height will be measured on this data. during the procedure of inserting a dental implant a trephine will be taken for histology.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- need extraction of single root tooth
- intend to have prosthetic implant in place of extraction
- treated with simvastatin P.O for hypercholesterolemia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description study group Simvastatin simvastatin will be inserted to sockets control Simvastatin sockets will be left to healing without material in socket
- Primary Outcome Measures
Name Time Method bone height and density in former socket 3 months measured on CT
- Secondary Outcome Measures
Name Time Method bone mineralization 3 months histology from bone in former socket
Trial Locations
- Locations (1)
Oral and Maxillofacial Clinic, Hadassah
🇮🇱Jerusalem, Israel