Effect of anti-cholesterol drug simvastatin to help in rapid bone healing in tooth extraction sockets
Phase 3
- Conditions
- Health Condition 1: K029- Dental caries, unspecified
- Registration Number
- CTRI/2020/04/024771
- Lead Sponsor
- Dr Ashi Chug
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Tooth requiring non surgical tooth extraction
Totally erupted tooth (carious tooth and root stump included)
Exclusion Criteria
Patients requiring tooth extraction with age of 18 years or less; or more than 50 years
Patient with medical co-morbidities like diabetes, hypertension, cardio-vascular disorders, bleeding disorders; disorders affecting bone metabolism
Patient with known cancer or undergoing/having history of radio-therapy/chemo-therapy
Patient who are allergic to the drug simvastatin
Patients on steroid therapy
Tooth requiring surgical tooth extraction
Un-erupted or partially erupted tooth
Tooth with peri-apical infection (peri-apical granuloma/cyst/abscess)
Pregnant patient
Patients lost to follow up
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study the bone mineral density in extraction socket in cases where simvastatin is used; by gray scale histogram at different time intervals of healingTimepoint: 1 week, 1 month, 2month, 4 months, 6 months, 8 months
- Secondary Outcome Measures
Name Time Method To compare pain and swelling at follow up: between case and controlTimepoint: 1 week, 1 month, 2 months, 4 months, 6 months, 8 months;To compare the alveolar ridge height obtained between case and controlTimepoint: 1 week, 1 month, 2 months, 4 months, 6 months, 8 months;To compare the bone mineral density with the control <br/ ><br>Timepoint: 1 week, 1 month, 2 months, 4 months, 6 months, 8 months;To compare the difference in bone mineral density obtained with the use of simvastatin: on maxilla and mandibleTimepoint: 1 week, 1 month, 2 months, 4 months, 6 months, 8 months;To compare the radiographic bone fill between case and controlTimepoint: 1 week, 1 month, 2 months, 4 months, 6 months, 8 months