Right ventricular contractile reserve and oxygen consumption in pulmonary arterial hypertensio

Conditions: Pulmonary arterial hypertension
10019280

Registration Number: NL-OMON50331

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 15

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
• Age >18 years
• Patients have to be diagnosed with idiopathic -, hereditary -, or drug- and
toxins induced PAH or chronic thrombo-embolic pulmonary hypertension (CTEPH)
conform ESC/ERS guidelines. PAH is diagnosed when the following criteria are
met:
o Mean Pulmonary Artery Pressure (mPAP) >= 25 mmHg
o Pulmonary Arterial Wedge Pressure (PAWP) > 15 mmHg
o Other possible causes of PAH are excluded

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:
• <1 year since last participation in research that included nuclear imaging
• Congenital heart disease
• Left sided heart disease
• Pulmonary Hypertension other than idiopathic -, hereditary -, or drug- and
toxins induced PAH or CTEPH
• Known coronary artery disease
• Pregnancy
• Malignancies
• Kidney failure
• Anemia (Hb < 8.0)
• Atrial fibrillation
• Use of β-blockers or a-blockers
• Use of ACE-inhibitors
• Age > 70 years

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters will be:<br /><br>• Myocardial oxygen consumption (kmono [C11]-acetate)<br /><br>• Contractility measured as end-systolic elastance (Ees). Which is calculated<br /><br>using the single beat method</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are:<br /><br>• Serum dihydroxyphenylacetic acid (DOPAC), dihydroxyphenylglycol (DHPG),<br /><br>norepinephrine (NE), normetanephrine (NMN), methoxyhydroxyphenylglycol (MHPG)<br /><br>which are metabolites of catecholamine degradation by monoamine oxidase (MAO).<br /><br>• Heart rate</p><br>