Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 4,100
- Locations
- 1
- Primary Endpoint
- Cognitive tasks and neuroimaging.
Study Overview
Brief Summary
The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks.
This study will use functional magnetic resonance imaging (fMRI) to examine blood flow to areas of the brain as participants engage in tasks associated with visual perception, visual recognition, and memory.
Detailed Description
Objective:
Our goal is to study the functional organization of the intact human brain by combining cognitive tasks and neuroimaging. Functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG) and electroencephalography (EEG) will be used to measure brain activity in healthy human subjects engaged in performing cognitive tasks. These tasks will address specific questions concerning the neural systems that mediate perception, attention, memory, decision-making, emotion, plasticity and social interactions. fMRI and MEG, respectively, will be employed to investigate the spatial and temporal aspects of these neural systems.
Study Population:
Normal volunteer participants aged 18-65, who are in good general health will be recruited from the local community and studied under this minimal risk protocol.
Design:
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •INCLUSION CRITERIA:
- •Healthy adults, with at least a high school education, aged 18 to 65 years, will be recruited to participate in the study.
- •Able to read and write in English to guarantee understanding of all written and spoken instructions, which are in English.
Exclusion Criteria
- •Subjects will be excluded if they:
- •have evidence of, or a history of:
- •major medical, neurological or psychiatric illness
- •serious head injury
- •learning disability-drug or alcohol abuse or dependence in the past 3 months, except nicotine
- •are taking prescription drugs or supplements that may affect brain function-
- •have serious vision or hearing problems
- •In addition to the above, additional exclusion criteria apply for all MRI studies:
- •Female subjects who are pregnant or have a positive pregnancy test 24 hours prior to an experiment will be excluded from neuroimaging studies.
- •All subjects will be questioned prior to MRI scanning for possible occupational exposure to metal slivers or shavings, which may have become accidentally lodged in the tissues of the head or neck. Subjects with surgical clips or shrapnel in or near the brain or blood vessels, subjects with cochlear implants, subjects with any metallic body in the eye or CNS, and subjects with any form of implant wire or metal device which may concentrate radiofrequency fields will be excluded from MRI scanning experiments because of possible risks during MRI scanning. Those whose history is suggestive of such a problem will also be excluded from the MRI portion of the experiments. They may still participate in the behavioral and MEG experiments.
- •Subjects unable to lie flat on their back for up to 3 hours may not be eligible to participate in MRI scans.
Arms & Interventions
1
Normal volunteer participants aged 18-65 who are in good general health.
Outcomes
Primary Outcomes
Cognitive tasks and neuroimaging.
Time Frame: ongoing
Cognitive tasks and neuroimaging.
Secondary Outcomes
No secondary outcomes reported