Physiologic Study of Cerebral Perfusion
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Global and regional cerebral blood flow
研究概览
简要总结
The aim of the study is to measure cerebral perfusion using MRI in healthy subjects (with and without sedation) and in vasopressor-dependent patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Shock lower Mean Arterial Pressure (MAP)
Vasopressor-dependent treated to lower MAP (65 mmHg)
干预措施: Lower doses of vasopressor therapy for a MAP of 65 mmHg (Drug)
Shock lower Mean Arterial Pressure (MAP)
Vasopressor-dependent treated to lower MAP (65 mmHg)
干预措施: Propofol for light sedation (Drug)
Shock higher MAP
Vasopressor-dependent treated to higher MAP (75 mmHg)
干预措施: Higher doses of vasopressor therapy for a MAP of 75 mmHg (Drug)
Shock higher MAP
Vasopressor-dependent treated to higher MAP (75 mmHg)
干预措施: Propofol for light sedation (Drug)
Healthy participant sedated
Healthy participant Under light sedation
干预措施: Propofol for light sedation (Drug)
结局指标
主要结局
Global and regional cerebral blood flow
时间窗: Within 15 minutes of intervention initiation
Cerebral blood flow will be measured by the arterial spin labeling technique (ASL) which provides information expressed in mL/100g/min. Using 3-T MRI technology,we will first acquire T1 images of the brain and sub-regions of interest. Thereafter, ASL sequences will be acquired in contiguous slices. The procedure will be followed on sedation and off sedation for healthy volunteers (in random order) and at mean arterial pressure of 65 mmHg and 75 mmHg (in random order) in patients receiving vasopressor therapy.
次要结局
未报告次要终点
研究者
François Lamontagne
Clinician Scientist
Université de Sherbrooke