Acute Medium Chain Triglycerides (MCT) Intake in Young and Older Participants

Not Applicable

Completed

• Conditions: Ketonemia
• Interventions: Dietary Supplement: No MCT intake with breakfast, no lunch; Dietary Supplement: No MCT intake with lunch, no breakfast; Dietary Supplement: 10g of Betaquik; Dietary Supplement: 10g of Betaquik with low-carbs breakfast; Dietary Supplement: 20g of Betaquik; Dietary Supplement: 10g of Betaquik with lunch, no breakfast

• Registration Number: NCT03830268
• Lead Sponsor: Université de Sherbrooke

Brief Summary

Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-02
• Study First Submitted: 2019-02-01
• Study First Submitted QC: 2019-02-04
• Study First Posted: 2019-02-05
• Primary Completion: 2019-06-25
• Study Completion: 2019-06-25
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-24
• Last Update Posted: 2020-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• 10 health young (20-40 y old) and 10 health older (> 60 y old) participants
• Men and women

Exclusion Criteria

• smoking
• diabetes (fasting glucose >7.0 mmol/l and glycated hemoglobin >6.9%)
• strenuous aerobic exercise more than three times a week
• untreated hypertension, dyslipidemia, and abnormal renal, liver, heart or thyroid function
• under medication known to affect triglycerides and carbohydrates metabolism (i.e. diuretics, beta-blockers, steroids, insulin sensitizing)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
MCT intake in young participants	10g of Betaquik with low-carbs breakfast	Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants. Interventions: 1. No MCT intake with breakfast, no lunch (i.e. CTL) 2. No MCT intake with lunch, no breakfast (i.e CTL inverted) 3. 10g of Betaquik with breakfast, no lunch (i.e BQ10) 4. 20g of Betaquik with breakfast, no lunch (i.e BQ20) 5. 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 6. 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
MCT intake in young participants	No MCT intake with breakfast, no lunch	Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants. Interventions: 1. No MCT intake with breakfast, no lunch (i.e. CTL) 2. No MCT intake with lunch, no breakfast (i.e CTL inverted) 3. 10g of Betaquik with breakfast, no lunch (i.e BQ10) 4. 20g of Betaquik with breakfast, no lunch (i.e BQ20) 5. 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 6. 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
MCT intake in young participants	10g of Betaquik	Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants. Interventions: 1. No MCT intake with breakfast, no lunch (i.e. CTL) 2. No MCT intake with lunch, no breakfast (i.e CTL inverted) 3. 10g of Betaquik with breakfast, no lunch (i.e BQ10) 4. 20g of Betaquik with breakfast, no lunch (i.e BQ20) 5. 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 6. 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
MCT intake in young participants	20g of Betaquik	Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants. Interventions: 1. No MCT intake with breakfast, no lunch (i.e. CTL) 2. No MCT intake with lunch, no breakfast (i.e CTL inverted) 3. 10g of Betaquik with breakfast, no lunch (i.e BQ10) 4. 20g of Betaquik with breakfast, no lunch (i.e BQ20) 5. 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 6. 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
MCT intake in young participants	No MCT intake with lunch, no breakfast	Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants. Interventions: 1. No MCT intake with breakfast, no lunch (i.e. CTL) 2. No MCT intake with lunch, no breakfast (i.e CTL inverted) 3. 10g of Betaquik with breakfast, no lunch (i.e BQ10) 4. 20g of Betaquik with breakfast, no lunch (i.e BQ20) 5. 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 6. 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
MCT intake in older participants	10g of Betaquik	Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in older participants. Interventions: 1. No MCT intake with breakfast, no lunch (i.e. CTL) 2. No MCT intake with lunch, no breakfast (i.e CTL inverted) 3. 10g of Betaquik with breakfast, no lunch (i.e BQ10) 4. 20g of Betaquik with breakfast, no lunch (i.e BQ20) 5. 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 6. 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)
MCT intake in young participants	10g of Betaquik with lunch, no breakfast	Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants. Interventions: 1. No MCT intake with breakfast, no lunch (i.e. CTL) 2. No MCT intake with lunch, no breakfast (i.e CTL inverted) 3. 10g of Betaquik with breakfast, no lunch (i.e BQ10) 4. 20g of Betaquik with breakfast, no lunch (i.e BQ20) 5. 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 6. 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)

Primary Outcome Measures

Name	Time	Method
Concentration of plasma ketones (acetoacetate and B-hydroxybutyrate)	8 hours	To compare acute ketonemia following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol.

Secondary Outcome Measures

Name	Time	Method
Concentration of plasma glucose	8 hours	To compare acute glucose following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol.
Concentration of plasma insulin	8 hours	To compare acute insulin following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol.
Concentration of plasma free fatty acids	8 hours	To compare acute free fatty acids following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol.

Trial Locations

Locations (1)

Rearsh Centre on Aging; 🇨🇦 Sherbrooke, Quebec, Canada