Effect of Medium Chain Triglyceride Intake on Colonization of Preterm Infants With Candida
Phase 1
Completed
- Conditions
- Candida InfectionPremature Infant
- Interventions
- Drug: Medium-Chain Triglyceride (MCT) Oil
- Registration Number
- NCT03630770
- Lead Sponsor
- Joseph Bliss
- Brief Summary
This study evaluates whether adding a dietary supplement similar to coconut oil (MCT oil) to feedings in premature infants will reduce the amount of yeast (Candida) detectable in their stool. Infants who have Candida in their stool are eligible to participate. Half of the enrolled infants will have additional MCT oil added to their feedings and half will not.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- Premature infant admitted to the Neonatal Intensive Care Unit at Women & Infants Hospital
- Receiving full enteral feeds of either preterm or transitional formula or fortified breast milk
- Anticipated to have a minimum stay of two weeks
Exclusion Criteria
- Prior exposure to antifungal drugs
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description MCT Oil Medium-Chain Triglyceride (MCT) Oil This group is supplemented with MCT oil
- Primary Outcome Measures
Name Time Method Stool Fungal Burden Before supplementation, 1 week after supplementation begins, 3 weeks (at conclusion of supplementation) Change in colony-forming units (cfu) of Candida per gram of stool. Data table reflects total number of stool samples collected from subjects in each group that were included in the analysis.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Women & Infants Hospital of Rhode Island
🇺🇸Providence, Rhode Island, United States