Observational, Multicenter, Cross-sectional Study at National Level to Analyze the Histopathological, Ultrastructural and Microbiological Findings Obtained in Autopsies of Patients Who Died Due to COVID-19 in Spain
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Covid19
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
- Enrollment
- 50
- Locations
- 10
- Primary Endpoint
- Histopathological and ultra-structural findings
- Last Updated
- 5 years ago
Overview
Brief Summary
The aim of this study is prospectively analyzing the histopathological, ultrastructural and microbiological findings from autopsies performed on patients with COVID-19.
Detailed Description
The aim of this study is to increase the knowledge of the pathogenic mechanisms of the COVID-19 disease, that will allow us to improve the design of clinical and therapeutic strategies against the disease. This is the tool to improve the prognosis of patients with COVID-19. The performance of systematic and regulated autopsies can help to manage it. However, despite the need to generate this knowledge and the strong impact on mortality caused by the COVID-19 pandemic, the evidence from post-mortem studies is very limited.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with COVID-19 infection confirmed by PCR.
- •Death related to active infection by COVID-19 or its complications.
- •Informed consent given by the subject's relatives to perform an autopsy according to the autonomous community requirements.
- •Informed consent given by the subject's relatives for the inclusion of samples in the Biobank.
Exclusion Criteria
- •COVID-19 infection diagnosed exclusively by serological methods.
- •Advanced or terminal chronic disease.
- •Inadequate security level of the autopsy room.
Outcomes
Primary Outcomes
Histopathological and ultra-structural findings
Time Frame: End of autopsy
To analyze the histopathological and ultra-structural findings obtained in complete and systematic autopsies of patients who died due to COVID-19.
Secondary Outcomes
- Histopathological / ultra-structural findings and clinical / biological expression correlation(End of autopsy)
- Molecular characterization(End of autopsy)
- Hidden pulmonary superinfections(End of autopsy)