The Effect of Aerobic Exercise on Learning After Stroke

Phase 1

Completed

• Conditions: Stroke
• Interventions: Behavioral: Rehabilitation exercise

• Registration Number: NCT00228306
• Lead Sponsor: University of Kansas

Brief Summary

Determine if attaining aerobic fitness is beneficial in producing cortical neuroplasticity in individuals with chronic stroke.

Detailed Description

Crossover clinical trial. Experimental group undergoes 3x/wk/6 months of aerobic conditioning. Control group performs usual daily activities. All participants will be assessed with cognitive and motor behavioral testing at baseline, 3, 6, 9 and 12 months.

Study Timeline

• Study Start: 2005-09
• Study First Submitted: 2005-09-26
• Study First Submitted QC: 2005-09-26
• Study First Posted: 2005-09-28
• Primary Completion: 2008-12
• Study Completion: 2009-12
• Status Verified: 2012-04
• Last Update Submitted: 2012-04-27
• Last Update Posted: 2012-05-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

• Single ischemic stroke occuring 6-72 months prior
• Fugl-Meyer score (upper + lower extremity) 45 or greater
• Mini mental status score of >23
• approval of the subject's medical doctor

Read More

Exclusion Criteria

• already performing >20 min of cardiovascular exercise 3x/wk or more
• alcohol consumption of >2 oz. liquor, 8 oz. wine or 24 oz beer/day
• cardiac history of unstable angina, recent myocardia infarction within the last 3 months, congestive heart failure, significant valve dysfunction
• medical history of recent hospitalization (> 3 months) for medical illness
• symptomatic peripheral arterial occlusive disease
• orthopedic or chronic pain conditions restricting exercise
• pulmonary or renal failure
• active cancer
• unstable hypertension (>160/100 mmHg)
• diabetes mellitus (fasting glucose > 180 NG./dk, HgA1C > 10%) that is unable to be controlled < month
• receptive or expressive aphasia as indicated on MMSE
• multiple strokes or other neuromuscular conditions
• major depression that is untreated using the Beck depression inventory

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
1	Rehabilitation exercise	-

Primary Outcome Measures

Name	Time	Method
Motor learning behavioral measures; executive function behavioral measures.	Baseline, 8 weeks, 12 weeks

Secondary Outcome Measures

Name	Time	Method
Peak V02 and other aerobic capacity measures. Physical disability measures.	Baseline, 8 weeks, 12 weeks

Trial Locations

Locations (1)

University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States