NCT00228306已完成1 期
Effect of Cardiovascular Fitness on Motor Learning and Executive Function in Individuals After Stroke
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- Motor learning behavioral measures; executive function behavioral measures.
研究概览
简要总结
Determine if attaining aerobic fitness is beneficial in producing cortical neuroplasticity in individuals with chronic stroke.
详细描述
Crossover clinical trial. Experimental group undergoes 3x/wk/6 months of aerobic conditioning. Control group performs usual daily activities. All participants will be assessed with cognitive and motor behavioral testing at baseline, 3, 6, 9 and 12 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Single ischemic stroke occuring 6-72 months prior
- •Fugl-Meyer score (upper + lower extremity) 45 or greater
- •Mini mental status score of >23
- •approval of the subject's medical doctor
排除标准
- •already performing >20 min of cardiovascular exercise 3x/wk or more
- •alcohol consumption of >2 oz. liquor, 8 oz. wine or 24 oz beer/day
- •cardiac history of unstable angina, recent myocardia infarction within the last 3 months, congestive heart failure, significant valve dysfunction
- •medical history of recent hospitalization (> 3 months) for medical illness
- •symptomatic peripheral arterial occlusive disease
- •orthopedic or chronic pain conditions restricting exercise
- •pulmonary or renal failure
- •active cancer
- •unstable hypertension (>160/100 mmHg)
- •diabetes mellitus (fasting glucose > 180 NG./dk, HgA1C > 10%) that is unable to be controlled < month
- •receptive or expressive aphasia as indicated on MMSE
- •multiple strokes or other neuromuscular conditions
- •major depression that is untreated using the Beck depression inventory
结局指标
主要结局
Motor learning behavioral measures; executive function behavioral measures.
时间窗: Baseline, 8 weeks, 12 weeks
次要结局
- Peak V02 and other aerobic capacity measures. Physical disability measures.(Baseline, 8 weeks, 12 weeks)
研究者
研究点 (2)
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