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Clinical Trials/NCT00228306
NCT00228306
Completed
Phase 1

Effect of Cardiovascular Fitness on Motor Learning and Executive Function in Individuals After Stroke

University of Kansas1 site in 1 country38 target enrollmentSeptember 2005
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ConditionsStroke

Overview

Phase
Phase 1
Intervention
Not specified
Conditions
Stroke
Sponsor
University of Kansas
Enrollment
38
Locations
1
Primary Endpoint
Motor learning behavioral measures; executive function behavioral measures.
Status
Completed
Last Updated
14 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Determine if attaining aerobic fitness is beneficial in producing cortical neuroplasticity in individuals with chronic stroke.

Detailed Description

Crossover clinical trial. Experimental group undergoes 3x/wk/6 months of aerobic conditioning. Control group performs usual daily activities. All participants will be assessed with cognitive and motor behavioral testing at baseline, 3, 6, 9 and 12 months.

Registry
clinicaltrials.gov
Start Date
September 2005
End Date
December 2009
Last Updated
14 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •Single ischemic stroke occuring 6-72 months prior
  • •Fugl-Meyer score (upper + lower extremity) 45 or greater
  • •Mini mental status score of \>23
  • •approval of the subject's medical doctor

Exclusion Criteria

  • •already performing \>20 min of cardiovascular exercise 3x/wk or more
  • •alcohol consumption of \>2 oz. liquor, 8 oz. wine or 24 oz beer/day
  • •cardiac history of unstable angina, recent myocardia infarction within the last 3 months, congestive heart failure, significant valve dysfunction
  • •medical history of recent hospitalization (\> 3 months) for medical illness
  • •symptomatic peripheral arterial occlusive disease
  • •orthopedic or chronic pain conditions restricting exercise
  • •pulmonary or renal failure
  • •active cancer
  • •unstable hypertension (\>160/100 mmHg)
  • •diabetes mellitus (fasting glucose \> 180 NG./dk, HgA1C \> 10%) that is unable to be controlled \< month

Outcomes

Primary Outcomes

Motor learning behavioral measures; executive function behavioral measures.

Time Frame: Baseline, 8 weeks, 12 weeks

Secondary Outcomes

  • Peak V02 and other aerobic capacity measures. Physical disability measures.(Baseline, 8 weeks, 12 weeks)

Study Sites (1)

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