Enhancing Synaptic Plasticity and Cognition in Schizophrenia
- Conditions
- Schizophrenia
- Registration Number
- NCT01776112
- Lead Sponsor
- University Medical Center Goettingen
- Brief Summary
To explore: (a) if physical exercise (sports) combined with cognitive training leads to (superior) improvement of cognition in schizophrenia compared to sports or cognitive training alone (b) if a sports program alone or in combination with cognitive training has influence on hippocampal pathology and synaptic plasticity in schizophrenia compared to a placebo condition.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 66
- Male and female patients with the diagnosis of schizophrenia (based on ICD-10 criteria)
- Age between 18 and 55
- Verbal IQ ≥ 85
- Stable psychopathology on constant medication for 2 weeks
- Informed consent.
Patients, who are
- not willing or able to participate in the sports program and cognitive training
- reveal a significant worsening of psychopathology (based on an increase over 20% of the PANSS positive score)
- have an organic mental disorder (such as intoxication or neurological disorders of the CNS)
- suffer from instable somatic diseases
- have an active substance abuse
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Hippocampal volume after three months of exercise Measurement of hippocampal volume before and after the exercise intervention, 3T-MRI MPRAGE-Sequence, manual and automated delineation of hippocampal borders
- Secondary Outcome Measures
Name Time Method Verbal Learning Memory after three months of exercise Neuropsychological assessment of a working memory domain via the Verbal Learning Memory Test (German: Helmstaedter, C., Lendt, M., Lux, S., 2001. Verbaler Lern- und Merkfähigkeitstest (VLMT). Göttingen, Beltz)
Positive and negative symptoms after three months of exercise Measurement of positive and negative symptoms of schizophrenia using the "Positive and Negative Symptom Scale for Schizophrenia" (Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261-76)
Trial Locations
- Locations (1)
Dept. of Psychiatry and Psychotherapy, University Medical Center Goettingen, Georg-August-University
🇩🇪Goettingen, Lower Saxony, Germany
Dept. of Psychiatry and Psychotherapy, University Medical Center Goettingen, Georg-August-University🇩🇪Goettingen, Lower Saxony, Germany