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Clinical Trials/NCT01776112
NCT01776112
Completed
Not Applicable

Enhancing Synaptic Plasticity and Cognition by Physical Exercise and Cognitive Training in Schizophrenia: A Randomised Controlled Trial

University Medical Center Goettingen1 site in 1 country66 target enrollmentJanuary 2011
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ConditionsSchizophrenia

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Schizophrenia
Sponsor
University Medical Center Goettingen
Enrollment
66
Locations
1
Primary Endpoint
Hippocampal volume
Status
Completed
Last Updated
10 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

To explore: (a) if physical exercise (sports) combined with cognitive training leads to (superior) improvement of cognition in schizophrenia compared to sports or cognitive training alone (b) if a sports program alone or in combination with cognitive training has influence on hippocampal pathology and synaptic plasticity in schizophrenia compared to a placebo condition.

Registry
clinicaltrials.gov
Start Date
January 2011
End Date
August 2014
Last Updated
10 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
University Medical Center Goettingen
Responsible Party
Principal Investigator
Principal Investigator

Prof. Dr. Peter Falkai

Prof. Dr. med. Peter Falkai

University Medical Center Goettingen

Eligibility Criteria

Inclusion Criteria

  • •Male and female patients with the diagnosis of schizophrenia (based on ICD-10 criteria)
  • •Age between 18 and 55
  • •Verbal IQ ≥ 85
  • •Stable psychopathology on constant medication for 2 weeks
  • •Informed consent.

Exclusion Criteria

  • •Patients, who are
  • •not willing or able to participate in the sports program and cognitive training
  • •reveal a significant worsening of psychopathology (based on an increase over 20% of the PANSS positive score)
  • •have an organic mental disorder (such as intoxication or neurological disorders of the CNS)
  • •suffer from instable somatic diseases
  • •have an active substance abuse

Outcomes

Primary Outcomes

Hippocampal volume

Time Frame: after three months of exercise

Measurement of hippocampal volume before and after the exercise intervention, 3T-MRI MPRAGE-Sequence, manual and automated delineation of hippocampal borders

Secondary Outcomes

  • Verbal Learning Memory(after three months of exercise)
  • Positive and negative symptoms(after three months of exercise)

Study Sites (1)

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