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临床试验/NCT04106128
NCT04106128已完成不适用

Prevalence, Impact and Reversibility of Acute Diaprhagmatic Dysfunction in Acute Respiratory Detresse Measured by Diaphragmatic Echogaphy

Centre Hospitalier Universitaire de Nice2 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2019年4月5日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
25
试验地点
2
主要终点
Thickening fraction

研究概览

简要总结

The diaphragm is a fine striated muscle with both extra respiratory and respiratory functions. It does most of the breathing work in interaction with the accessory respiratory muscles, the rib cage and the abdomen. Its activity can be measured by the transdiaphragmatic pressure generated by the magnetic stimulation of phrenic nerves (gold standard). It has been shown in the literature that diaphragmatic ultrasound, via the measurement of diaphragmatic excursion and especially the thickening fraction, is an easily accessible, non-invasive, reproducible and relevant technique for evaluating acute diaphragmatic dysfunction in resuscitation patients.

The objective of this project is to evaluate the prevalence of diaphragmatic dysfunction at admission in patients hospitalized in intensive care / respiratory intensive care unit for hypercapnic and/or hypoxic acute respiratory distress and requiring ventilatory support by non-invasive ventilation or high flow oxygen therapy. A subgroup analysis will then be carried out on 3 populations:

  • Hypercapnic exacerbation of chronic obstructive pulmonary disease
  • Hypoxic acute respiratory distress on infectious lung disease
  • Acute pulmonary edema

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Hospitalization for acute respiratory distress management
  • Etiological diagnosis either:
  • Exacerbation of chronic obstructive pulmonary disease
  • Infectious pneumonitis
  • Acute pulmonary edema
  • Need for a ventilatory support by either:
  • Non-invasive ventilation
  • High flow oxygen therapy (flow rate > 40L/min and oxygen inspired fraction > 40%)
  • Mask oxygen therapy with flow rate > 5L/min

排除标准

  • Exacerbation of interstitial pathology / pulmonary fibrosis
  • Deformation of the thoracic cage
  • Neurodegenerative pathology
  • Need for oro-tracheal intubation from the beginning for mechanical ventilation
  • Contraindication to Non-invasive Ventilation
  • Patients undergoing diaphragmatic rehabilitation
  • Immunocompromised patients
  • History of known diaphragmatic dysfunction

结局指标

主要结局

Thickening fraction

时间窗: 48 hours

Measurement of the thickening fraction by diaphragmatic ultrasound

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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