Comparison of the Effects of Weight Changes on Serum Adipokines in Patients Diagnosed With Anorexia Nervosa and Morbid Obesity
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Istanbul University
- Enrollment
- 55
- Primary Endpoint
- Plasma Leptin levels changes:
Study Overview
Brief Summary
In this study, when patients diagnosed with AN started treatment and their weight increased by 10%; On the other hand, it was aimed to compare the changes in serum adipokine levels observed in morbidly obese patients before bariatric surgery and when they lost 10% of their post-op weight with both anthropometric measurements, biochemical parameters, and values of healthy volunteers.
Detailed Description
The most characteristic feature of obesity is the increase in adipose tissue. On the contrary, in anorexia nervosa, there is a decrease in adipose tissue enough to impair neuroendocrine functions. Adipose tissue is formed by loosely binding lipid-filled cells called adipocytes and is now considered an important part of energy metabolism. Adipokines it secretes play a role in many physiological processes of the body such as nutrition, appetite, energy balance, insulin, and glucose metabolism, lipid metabolism, regulation of blood pressure, vascular remodeling, coagulation, and inflammation.
Therefore, changes in the amount of body fat in these two patient groups, which are at the two ends of the spectrum, affect both the biochemical parameters and physiological functions of the patients in different ways. It is expected that both adipokine levels and biochemical parameters will approach the values of healthy subjects with a decrease in adipose tissue of clinically morbidly obese patients and an increase in adipose tissue of patients with AN. However, in some studies comparing the parameters of patients with constitutionally weak patients and patients with AN, results contrary to expectations were obtained. In this study, we compared the extent to which weight changes changed adipokines and correlated with biochemical parameters based on healthy and normal-weight volunteers.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 13 Years to 60 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •for Anorexia Nervosa group:
- •Have been diagnosed with anorexia nervosa
- •BMI <18 kg/m2
- •Good general health
- •Volunteering to participate in the study
- •for Morbidly Obese group:
- •Who was diagnosed with morbid obesity and planned to undergo RYGB operation
- •BMI> 40 kg/m2
- •Volunteering to participate in the study
- •for Healthy Volunteers:
- •Good general health
- •BMI >20 and <30 kg/m2
- •Volunteering to participate in the study
Exclusion Criteria
- •<13 and> 60 years old
- •to had type 2 diabetes, hypertension, liver and kidney failure, cancer, or a chronic disease
Outcomes
Primary Outcomes
Plasma Leptin levels changes:
Time Frame: 3 months on average
Change in baseline Leptin levels at when decreasing by 10 percent or increasing by 10 percent from initial weight. Measured by plasma samples.
Plasma Apelin levels changes
Time Frame: 3 months on average
Change in baseline Apelin levels at when decreasing by 10 percent or increasing by 10 percent from initial weight. Measured by plasma samples.
Plasma Omentin levels changes
Time Frame: 3 months on average
Change in baseline Omentin levels at when decreasing by 10 percent or increasing by 10 percent from initial weight. Measured by plasma samples.
Plasma Adiponectin levels changes
Time Frame: 3 months on average
Change in baseline Adiponectin levels at when decreasing by 10 percent or increasing by 10 percent from initial weight. Measured by plasma samples.
Plasma IL-6 levels changes
Time Frame: 3 months on average
Change in baseline IL-6 levels at when decreasing by 10 percent or increasing by 10 percent from initial weight. Measured by plasma samples.
Secondary Outcomes
- Weight change(3 months on average)
- Fat mass change(3 months on average)
- Fat free mass changes(3 months on average)
Investigators
Fulya Turker
MD, PhD; Academivian; Principle Investigator
Istanbul University