Comparison of the Effects of Weight Changes on Serum Adipokines in Patients Diagnosed With Anorexia Nervosa and Morbid Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 55
- 主要终点
- Plasma Leptin levels changes:
研究概览
简要总结
In this study, when patients diagnosed with AN started treatment and their weight increased by 10%; On the other hand, it was aimed to compare the changes in serum adipokine levels observed in morbidly obese patients before bariatric surgery and when they lost 10% of their post-op weight with both anthropometric measurements, biochemical parameters, and values of healthy volunteers.
详细描述
The most characteristic feature of obesity is the increase in adipose tissue. On the contrary, in anorexia nervosa, there is a decrease in adipose tissue enough to impair neuroendocrine functions. Adipose tissue is formed by loosely binding lipid-filled cells called adipocytes and is now considered an important part of energy metabolism. Adipokines it secretes play a role in many physiological processes of the body such as nutrition, appetite, energy balance, insulin, and glucose metabolism, lipid metabolism, regulation of blood pressure, vascular remodeling, coagulation, and inflammation.
Therefore, changes in the amount of body fat in these two patient groups, which are at the two ends of the spectrum, affect both the biochemical parameters and physiological functions of the patients in different ways. It is expected that both adipokine levels and biochemical parameters will approach the values of healthy subjects with a decrease in adipose tissue of clinically morbidly obese patients and an increase in adipose tissue of patients with AN. However, in some studies comparing the parameters of patients with constitutionally weak patients and patients with AN, results contrary to expectations were obtained. In this study, we compared the extent to which weight changes changed adipokines and correlated with biochemical parameters based on healthy and normal-weight volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 13 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for Anorexia Nervosa group:
- •Have been diagnosed with anorexia nervosa
- •BMI <18 kg/m2
- •Good general health
- •Volunteering to participate in the study
- •for Morbidly Obese group:
- •Who was diagnosed with morbid obesity and planned to undergo RYGB operation
- •BMI> 40 kg/m2
- •Volunteering to participate in the study
- •for Healthy Volunteers:
- •Good general health
- •BMI >20 and <30 kg/m2
- •Volunteering to participate in the study
排除标准
- •<13 and> 60 years old
- •to had type 2 diabetes, hypertension, liver and kidney failure, cancer, or a chronic disease
研究组 & 干预措施
Anorexia Nervosa
Patients diagnosed with Anorexia Nervosa, having a BMI of <18, being followed up and treated in the Psychiatry Eating Disorders Polyclinic and endocrinology outpatient clinics, and who have approximately 10% weight gain during the treatment process
干预措施: Dietary intervention (Behavioral)
Morbidly Obese
Patients with a BMI> 40 diagnosed with Morbid Obesity and who lost approximately 10% of their weight by performing obesity surgery (gastric bypass or sleeve gastrectomy)
干预措施: Bariatric surgery-RYGB (Procedure)
Healthy Volunteer
Volunteers with normal BMI and without any additional chronic disease
结局指标
主要结局
Plasma Leptin levels changes:
时间窗: 3 months on average
Change in baseline Leptin levels at when decreasing by 10 percent or increasing by 10 percent from initial weight. Measured by plasma samples.
Plasma Apelin levels changes
时间窗: 3 months on average
Change in baseline Apelin levels at when decreasing by 10 percent or increasing by 10 percent from initial weight. Measured by plasma samples.
Plasma Omentin levels changes
时间窗: 3 months on average
Change in baseline Omentin levels at when decreasing by 10 percent or increasing by 10 percent from initial weight. Measured by plasma samples.
Plasma Adiponectin levels changes
时间窗: 3 months on average
Change in baseline Adiponectin levels at when decreasing by 10 percent or increasing by 10 percent from initial weight. Measured by plasma samples.
Plasma IL-6 levels changes
时间窗: 3 months on average
Change in baseline IL-6 levels at when decreasing by 10 percent or increasing by 10 percent from initial weight. Measured by plasma samples.
次要结局
- Weight change(3 months on average)
- Fat mass change(3 months on average)
- Fat free mass changes(3 months on average)
研究者
Fulya Turker
MD, PhD; Academivian; Principle Investigator
Istanbul University