Active Detection of the Extension of Atherothrombosis in High Risk Coronary Patients
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT00445835
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Brief Summary
Coronary artery disease is the first cause of death related to atherothrombosis.
- Detailed Description
Coronary artery disease is the first cause of death related to atherothrombosis. There is a close correlation between the extension of coronary artery disease and the severity of atherosclerotic lesions in extra coronary arterial beds. In addition, these symptomatic extracoronary lesions dramatically decrease the survival of these patients. However, scant data are available regarding the prevalence of extracoronary asymptomatic lesions. Conversely, the annual absolute risk of these lesions remains unknown. Consequently, whether a systematic identification of these extracoronary asymptomatic lesions is relevant remains to be established. The Primary Objective and Primary Endpoint of the AMERICA study is to demonstrate the superiority of an active detection and management of the extension of atherothrombosis in high Risk coronary patients (active strategy) in comparison with standard of care for coronary atherosclerosis (conservative strategy).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 526
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method death (all cause) or any ischemic event leading to rehospitalisation or any evidence of organ failure. during the study death (all cause) or any ischemic event leading to rehospitalisation or any evidence of organ failure.
- Secondary Outcome Measures
Name Time Method Incidence of each composite of the primary endpoint. during the study Incidence of each composite of the primary endpoint.
Trial Locations
- Locations (1)
Hopital Pitie-Salpetriere
🇫🇷Paris, France
Hopital Pitie-Salpetriere🇫🇷Paris, France