Reduced incidence of nausea and vomiting (PONV) in sevoflurane anaesthesia due to low-dose propofol infusio

Not Applicable

Recruiting

Conditions: M16.1
K40.9
Other primary coxarthrosis
Unilateral or unspecified inguinal hernia, without obstruction or gangrene

Registration Number: DRKS00008568

Lead Sponsor: Park-Klinik WeissenseeAbteilung Anästhesiologie Intensivmedizin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 686

Inclusion Criteria

Patients undergoing elective surgery under general anaesthesia

Endotracheal intubation

Minimum age of 18 years

ASA-classification I-III

Minimum duration of operation 30 minutes

Good knowledge of German for understanding

Exclusion Criteria

Lack of willingness to accept storage and transfer of pseudonymised health data
Emergency surgery
Pregnancy
Inoperable regarding the ASA-classification
Artificial ventilation postoperatively
Lack of an informed consent
Age under 18 years
Participation in an other study during the last three month
Mental disorders
History of an adverse reaction to study medication

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prevalence and severity of PONV (acquired by postoperative questionnaire, day of surgery, first and second postoperative day)

Secondary Outcome Measures

Name	Time	Method
sevoflurane concentration( Vol%exp) at a given depth of anaesthesia (Narcotrend-signal: D2-E0) and a fix propofol dosage (1 µg/ml, TCI-modus) [intraoperative measurement]<br><br>use of vasoactive substances such as norepinephrine [intraoperative measurement and recovery room]<br><br>pain level and need in analgesics postoperatively [recovery room, day of surgery, first and second postoperative day]<br><br>duration of stay in recovery room [postoperative measurement]<br><br>cognitive function [1 day preoperatively, recovery room, first and second postoperative day]<br><br><br>