Neurobiological Changes and Clinical Outcome When Treating Depression With Electroconvulsive Therapy.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Measures of hippocampal volume assessed by structural MRI
研究概览
简要总结
The purpose of this study is to determine functional and structural changes in brain following treatment of severe depression with electroconvulsive therapy with correlation to clinical outcome. Our hypothesis is that there are state-dependent changes in functional connectivity within specific neurocircuits systems, as well as structural plasticity changes in hippocampus, when recovering from depression.
详细描述
The study is a prospective, within-subject, observational follow-up study in individuals with depression who receive electroconvulsive therapy (ECT)at a psychiatric clinic. We will use a consecutive sampling method and patient referred for ECT by their psychiatrist will be screened for inclusion and asked for participation. Both in - and outpatients can be included. At three occasions (before treatment, after four week and after three months) patients will be assessed with clinical ratings, cognitive tests, functional and structural magnetic resonance imaging and biomarkers for cell proliferation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •major depressive disorder
- •depressive episode in bipolar disorder
- •age 18 - 65 years
排除标准
- •alcohol- and/or drug dependence or abuse in the past 3 months
- •severe/life-threatening medical disease
- •pregnancy
- •type I diabetes
- •neurodegenerative disorder
- •inability to give written informed consent to participation in the study
- •contradiction to MRI scanning.
结局指标
主要结局
Measures of hippocampal volume assessed by structural MRI
时间窗: Three months
fMRI BOLD resting state functional connectivity
时间窗: 3 month
fMRI BOLD responses during execution of emotional and reward processing tasks
时间窗: 3 months
Biomarkers of cell proliferation
时间窗: 3 months
次要结局
- Relation between neurobiological changes and clinical and cognitive outcome(Three months)
研究者
Pia Nordanskog
MD
Linkoeping University