Optic Nerve Sheath Diameter in Preeclampsia

Not Applicable

Completed

• Conditions: Pre-Eclampsia
• Interventions: Diagnostic Test: Optic nerve sheath diameter measurement

• Registration Number: NCT04004897
• Lead Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Brief Summary

Severe preeclampsia is associated with an elevation in intracranial pressure (ICP). Optic nerve sheath diameter is a non-invasive surrogate of invasive ICP measurement. This study targets to evaluate the ICP in patients with or without preeclampsia.

Detailed Description

MRI studies have shown that brain edema due to an elevation in ICP develops in up to 70% of women with preeclampsia. Optic nerve sheath diameter is used to estimate the ICP and has been shown to correlate well with invasive ICP measurement. The present study aims to compare ICP using optic nerve sheath diameter in women with or without preeclampsia.

Study Timeline

• Study First Submitted: 2019-06-30
• Study First Submitted QC: 2019-07-01
• Study First Posted: 2019-07-02
• Study Start: 2019-07-05
• Primary Completion: 2019-11-20
• Study Completion: 2019-11-25
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-19
• Last Update Posted: 2020-02-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

• Must be diagnosed as preeclampsia
• Age must be > 18 years

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Exclusion Criteria

• History of previous intracranial pathology or surgery
• Glaucoma

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pregnants without preeclampsia	Optic nerve sheath diameter measurement	Pregnant women without preeclampsia will receive optic nerve sheath diameter measurement with a linear ultrasound probe carefully and gently placed on the closed upper eyelids of patients.
Preeclampsia group	Optic nerve sheath diameter measurement	Patients with preeclampsia will receive optic nerve sheath diameter measurement with a linear ultrasound probe carefully and gently placed on the closed upper eyelids of patients.

Primary Outcome Measures

Name	Time	Method
ICP	At 6th hour of admission	The difference in ICP estimated with optic nerve sheath diameter measurement among women with or without preeclampsia

Trial Locations

Locations (1)

Kanuni Sultan Suleyman Training and Research Hospital; 🇹🇷 Istanbul, Please Enter The State Or Province, Turkey