Ocular Ultrasonography as a Tool for Monitoring the Management of Traumatic Brain Injury
- Conditions
- Traumatic Brain Injury
- Interventions
- Diagnostic Test: Optic nerve sheath diameter
- Registration Number
- NCT03795896
- Lead Sponsor
- Mansoura University Hospital
- Brief Summary
Raised intracranial pressure (ICP) is a common and life threatening condition especially in patients with traumatic brain injury.There are many methods for monitoring the increased (ICP) either invasive or non- invasive ,but the gold standard is invasive method. Optic nerve sheath ultrasonography provides a very promising bedside tool for detection of increased ICP. This study will monitor the dynamic changes of intracranial pressure by optic nerve sheath diameter (ONSD) in response to mannitol osmotherapy
- Detailed Description
Traumatic brain injury is the main cause of increased intracranial pressure (ICP) in the intensive care .
There are multiple methods for monitoring the raised ICP either invasive or non-invasive.The gold standard is the invasive devices because it is more accurate and reliable .However ,it requires a surgical intervention which has many hazards such as (infection ,hemorrhage,malfunction ).
Optic nerve sheath ultrasonography is a promising bedside tool for detection of increased ICP. The optic nerve is surrounded by cerebro-spinal fluid ,thus if the circulation of cerebro-spinal fluid not blocked ,an increase in ICP will be transmitted through the subarachnoid space around the optic nerve within the nerve sheath especially the retro-bulbar segment.
The study will be conducted to monitor the dynamic changes of intracranial pressure by optic nerve sheath diameter (ONSD) in response to mannitol osmotherapy as a primary outcome and secondary to evaluate the efficacy of ONSD in assessing the severity of the disease
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
- Patients with traumatic brain injury
- Patients with history of optic neuritis
- past history of eye trauma
- patient with optic nerve trauma
- patient with history of arachnoid cyst of the optic nerve
- high myopic patients
- patients with cavernous sius mass
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Optic nerve sheath diameter Optic nerve sheath diameter The intracranial pressure will be measured by optic nerve sheath diameter while the patient in supine position with 30 -degree bed position .The linear probe in the two -dimensional mode will be placed gently on the upper eyelid without pressure .In linear horizontal orientation for both right and left optic nerve sheath will be measured
- Primary Outcome Measures
Name Time Method Assessing the changes in the intracranial pressure from 20 minutes before mannitol therapy (basal reading) till 48 hours after the end of mannitol infusion It will be monitored and recorded the changes in intracranial pressure to the mannitol therapy .Basal (before mannitol therapy).20 minutes after the end of mannitol infusion ,2 hours ,6 hours,12 hours ,24 hours and 48 hours after the end of mannitol infusion
- Secondary Outcome Measures
Name Time Method Assessing the changes in the mean arterial pressure from 20 minutes before mannitol therapy(basal reading) till 48 hours after the end of mannitol infusion It will be calculated according to the formula systolic blood pressure+2(diastolic blood pressure)recorded basal (before mannitol therapy).20 minutes after the end of mannitol infusion ,2 hours ,6 hours,12 hours ,24 hours and 48 hours after the end of mannitol infusion
Assessing the changes in the heart rate from 20 minutes before mannitol therapy (basal reading ) till 48 hours after the end of mannitol infusion It will be recorded basal (before mannitol therapy).20 minutes after the end of mannitol infusion ,2 hours ,6 hours,12 hours ,24 hours and 48 hours after the end of mannitol infusion
Trial Locations
- Locations (1)
Reem Abdelraouf Elsharkawy
🇪🇬Mansourah, Dakahlia, Egypt