Improving Safety during Cancer Surgery: Investigating the Impact of Different Techniques of of Mechanical Ventilation on Blood Pressure Drops after Anesthesia - A Clinical Study
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/06/054245
- Lead Sponsor
- MPMMCC Tata Memorial Centre Varanasi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Consenting patients of 18 - 65 years of age, of ASA Physical Status 1 and 2, posted for major cancer surgeries under general anesthesia with controlled mechanical ventilation, with or without regional analgesia.
Pregnant women, patients below 18 years of age, or above 65 years age.
Patients of ASA physical status 3, 4 and 5, or severe cardiovascular, respiratory, neurological, renal, hepatic, and coagulation disorders.
Patients posted for emergency surgeries.
Patients with fasting periods of more than 2 hours (continuing on clear fluids, after the last meal beyond 6 hours).
Patients whose airways are secured by tracheostomy or awake tracheal intubation, or rapid sequence induction and intubation, and patients with anticipated difficult airway.
Patients not willing to participate in the study.
Patients in whom regional analgesia is planned to be administered prior to induction of general anesthesia.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of hypotension after induction of general anesthesiaTimepoint: Immediately after induction of general anesthesia, 1 minute, 2 minutes and 3 minutes after induction of general anesthesia
- Secondary Outcome Measures
Name Time Method End Tidal CO2 <br/ ><br>Oxygen saturation <br/ ><br>Heart rate <br/ ><br>Peak airway pressure <br/ ><br>Plateau airway pressure <br/ ><br>PEEP <br/ ><br>Total requirement (mg) of intravenous mephentermine injection to correct hypotension <br/ ><br>Any adverse effectsTimepoint: immediate preinduction, <br/ ><br>immediately after induction of general anesthesia, <br/ ><br>1 minute, <br/ ><br>2 minutes, <br/ ><br>3 minutes after induction of general anesthesia