Effects of mild versus moderate training in patients with heart failure.
- Conditions
- Heart failure, inflammation, oxidative stressC14.280.434C23.550.470GO3.495.710
- Registration Number
- RBR-3ypm3f
- Lead Sponsor
- Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- not yet recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Patients with diagnosis of heart failure for at least six months, clinically stable for at least two months before this study.
Left ventricular ejection fraction < 45%.
Aging between 25 and 59 years old.
Body mass index (BMI) < 30 kg/m2.
Stage C of the guidelines from the American College of Cardiology and American Heart Association (2005).
Classes I to III from the New York Heart Association (NYHA).
Sedentary, as defined by American College of Sports Medicine (2007).
User of cardiac pacemaker.
Inflammatory diseases in acute phase;
Renal insufficiency.
Orthopedic or neurological impairments which limit the exercise performance.
History of respiratory disease, unstable angina, uncontrolled arrhythmias or peripheral obstructive arterial disease.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Inflammatory markers: interleukin-6 (IL-6) and soluble tumor necrosis factor alpha receptor-1 (sTNFR1), measured by ELISA method.;Oxidative stress: malondialdehyde, enzymes superoxide dismutase, catalase and glutathione peroxidase, by enzymatic methods.;Quality of life (scores of the Minnesota Living with Heart Failure Questionnaire).
- Secondary Outcome Measures
Name Time Method Results of cardiopulmonary exercise test: peak oxygen uptake (VO2peak), oxygen pulse (VO2/HR), anaerobic threshold (AT), markers of ventilatory efficiency (eg, the VE/VCO2 slope and oxygen uptake efficiency slope - OUES and exercise oscillatory ventilation - EOV).;Six-minute walk test (distance).<br>